Toll-like receptors (TLRs) are a family of pattern recognition receptors that are expressed on cells of the innate immune system. The ligands can be pathogen derived (pathogen associated molecular patterns; PAMPs) or endogenous (damage associated molecular patters; DAMPs) that when bound induces activation of nuclear factor kappa B (NF-κB) and transcription of pro-inflammatory genes. TLRs have also been discovered in various malignant cell types, but with unknown function.
The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Cancer immunology (013031800), Clinical pathology, Malmö (013017551), Experimental Infection Medicine (013017505), Faculty of Medicine (000022000), Oncology, MV (013035000), Pathology, (Lund) (013030000)