Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

Anirban Bhattachariya; Diana Dahan; Karolina Turczynska; Karl Swärd; Per Hellstrand; Sebastian Albinsson

doi:10.1093/cvr/cvt253

Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

Anirban Bhattachariya, Diana Dahan, Karolina Turczynska, Karl Swärd, Per Hellstrand, Sebastian Albinsson

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Sammanfattning

The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.

Originalspråk	engelska
Sidor (från-till)	288-296
Tidskrift	Cardiovascular Research
Volym	101
Nummer	2
DOI	https://doi.org/10.1093/cvr/cvt253
Status	Published - 2014

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Kardiologi

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10.1093/cvr/cvt253

Oxford_Bhattachariya_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24233972?dopt=Abstract

1 Doktorsavhandling (sammanläggning)

Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2
Bhattachariya, A., 2014, Vascular Physiology, Lund University. 89 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

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title = "Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.",

abstract = "The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.",

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journal = "Cardiovascular Research",

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T1 - Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

AU - Bhattachariya, Anirban

AU - Dahan, Diana

AU - Turczynska, Karolina

AU - Swärd, Karl

AU - Hellstrand, Per

AU - Albinsson, Sebastian

PY - 2014

Y1 - 2014

N2 - The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.

AB - The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.

U2 - 10.1093/cvr/cvt253

DO - 10.1093/cvr/cvt253

M3 - Article

C2 - 24233972

SN - 1755-3245

VL - 101

SP - 288

EP - 296

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 2

ER -

Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

Sammanfattning

Ämnesklassifikation (UKÄ)

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Forskningsoutput

Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2

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