Familial colorectal cancer type X: genetic profiles and phenotypic features.

Mev Dominguez, Christina Therkildsen, Sabrina Da Silva, Mef Nilbert

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

34 Citeringar (SciVal)

Sammanfattning

Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.Modern Pathology advance online publication, 18 April 2014; doi:10.1038/modpathol.2014.49.
Originalspråkengelska
Sidor (från-till)30-36
TidskriftModern Pathology
Volym28
Nummer1
DOI
StatusPublished - 2015

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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