Fast simulation of pharmacokinetics

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Fast simulation of linear time-invariant (LTI) pharmacokinetic (PK) models is crucial to mixed-effect modeling techniques, used extensively in pharmacological research and development. The by far most common LTI PK models are particularly structured compartmental systems with one, two or three compartments. Here we develop and demonstrate very efficient, and down to machine precision exact, simulators for those structures. Our proposed method is benchmarked against state-of-the art software for simulation of linear systems, using a clinically relevant data set.
Originalspråkengelska
Sidor (från-till)2995-3000
TidskriftIFAC Proceedings Volumes (IFAC-PapersOnline)
Volym56
Nummer2
DOI
StatusPublished - 2023
Evenemang22nd IFAC World Congress - Yokohama, Japan
Varaktighet: 2023 juli 92023 juli 14
https://www.ifac2023.org

Ämnesklassifikation (UKÄ)

  • Reglerteknik
  • Farmakologi och toxikologi

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