Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species

Mattias Gustafsson, Colin N. Palmer, Roland C. Wolf, Claes von Wachenfeldt

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

21 !!Citations (SciVal)

Sammanfattning

Bacillus subtilis strain 168 encodes two flavocytochromes P450, Cyp102A2 and Cyp102A3. The cyp102A3 gene is preceded by, and organized in an operon with, a gene for a transcriptional regulator, encoded by fatR. The paralogous gene, cyp102A2, is most likely transcribed as a mono-cistronic message. We show that fatR encodes a protein that binds to an operator sequence that is present upstream of its own reading frame, thereby repressing the expression of the fatR-cyp102A3 operon. Unsaturated fatty acids and phytanic acid have the capacity to interact with FatR and to abrogate its binding to the operator sequence.
Originalspråkengelska
Sidor (från-till)459-464
TidskriftArchives of Microbiology
Volym176
Utgåva6
DOI
StatusPublished - 2001

Ämnesklassifikation (UKÄ)

  • Immunologi inom det medicinska området
  • Mikrobiologi inom det medicinska området

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