Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

Cristina Cudalbu, Arnaud Comment, Fiodar Kurdzesau, Ruud B. van Heeswijk, Kai Uffmann, Sami Jannin, Vladimir Denisov, Deniz Kirik, Rolf Gruetter

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

80 Citeringar (SciVal)

Sammanfattning

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized N-15 labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized N-15 labeled choline in live animals.
Originalspråkengelska
Sidor (från-till)5818-5823
TidskriftPhysical Chemistry Chemical Physics
Volym12
Utgåva22
DOI
StatusPublished - 2010

Ämnesklassifikation (UKÄ)

  • Neurovetenskaper

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