First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

J. Schouenborg, B. H. Sjölund

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.

Originalspråkengelska
Sidor (från-till)394-398
Antal sidor5
TidskriftBrain Research
Volym379
Nummer2
DOI
StatusPublished - 1986 aug. 6

Ämnesklassifikation (UKÄ)

  • Neurovetenskaper

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