Sammanfattning
We could determine the S-phase fraction (SPF) by flow cytometric DNA analysis of paraffin archival material in 160 of 260 patients with soft-tissue sarcoma of extremity and trunk wall. The prognostic value of SPF was compared with other clinicopathological factors. The median follow-up time was 16 (6-31) years. In a univariate analysis, deep tumour location, increasing tumour size and histological malignancy grade, microscopic tumour necrosis, vascular invasion, DNA non-diploidy and high SPF (>3.0%) were associated with poor metastasis-free survival. In a multivariate analysis, microscopic tumour necrosis and high SPF were independently prognostic for metastasis. Used in combination with tumour size, microscopic tumour necrosis and vascular invasion, SPF could identify a group of patients with a 5-year metastasis-free survival rate of 0.97. This group constituted one-quarter of all patients. Patients with low SPF who did recur had a prolonged clinical course both as regards metastases and local recurrence. We conclude that SPF is a valuable adjunct in prognostication in soft-tissue sarcoma.
Originalspråk | engelska |
---|---|
Sidor (från-till) | 94-100 |
Tidskrift | British Journal of Cancer |
Volym | 75 |
Nummer | 1 |
Status | Published - 1997 |
Bibliografisk information
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Pathology, (Lund) (013030000), Department of Orthopaedics (Lund) (013028000), Oncology, MV (013035000)
Ämnesklassifikation (UKÄ)
- Cancer och onkologi