Frequent intratype neutralization by plasma immunoglobulin A identified in HIV-2 infection.

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Sammanfattning

Human immunodeficiency virus type 2 (HIV-2) is less transmissible and less pathogenic compared to HIV-1 and, when matched for CD4+ T cell count, the plasma viral load in HIV-2 infected individuals is approximately one log lower than in HIV-1 infected individuals. The explanation for these observations is elusive, but differences in virus controlling immunity generated in the two infections may be contributing factors. In the present study, we investigated neutralization by immunoglobulin A (IgA), in parallel with IgG, purified from plasma of HIV-1, HIV-2 and HIV-1/HIV-2 dually (HIV-D)-infected individuals. Neutralization was analyzed against HIV-1 and HIV-2 isolates using a plaque reduction assay. In HIV-2 infection, intratype-specific neutralization by IgA was frequently detected, although at a lesser magnitude then the corresponding IgG neutralizing titers. In contrast, neutralization by IgA could rarely be demonstrated in HIV-1 infection despite similar plasma IgA levels in both infections. In addition, IgA and IgG of HIV-D plasma neutralized the HIV-2 isolate more potently than the HIV-1 isolate, suggesting that the difference between neutralizing activity of plasma IgA and IgG depends on the virus itself. Taken together, these findings suggest that both IgA and IgG adds to the potent intratype neutralizing activity detected in HIV-2 plasma, which may contribute to virus control in HIV-2 infection.
Originalspråkengelska
Sidor (från-till)470-478
TidskriftAIDS Research and Human Retroviruses
Volym29
Nummer3
DOI
StatusPublished - 2013

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000), Clinical Microbiology, Malmö (013011000), Division of Medical Microbiology (013250400), Faculty of Medicine (000022000), Clinical Virology, Malmö (013017580), Infectious Diseases Research Unit (013242010), Molecular Virology (013212007), Division of Hematology and Transfusion Medicine (013041100)

Ämnesklassifikation (UKÄ)

  • Infektionsmedicin

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