Functional imaging of the renal cortex with 18F-PSMA-1007 PET

Kristian Valind

Functional imaging of the renal cortex with ¹⁸F-PSMA-1007 PET

Kristian Valind

Klinisk fysiologi och nuklearmedicin, Malmö

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

44 Nedladdningar (Pure)

Sammanfattning

Background: Scintigraphy of the renal cortex with technetium-99m labelled dimercaptosuccinic acid (^99mTc-DMSA) is well established in the follow-up of pyelonephritis in children. This method allows detection of focal defects of renal function, as well as measurement of the relative contribution of each kidney to total renal function - split renal function (SRF). Within nuclear medicine, the long trend shows an ongoing shift from gamma camera imaging (such as with ^99mTc-
DMSA) to positron emission tomography (PET), mainly due to higher technical performance. In this thesis, a PET radiopharmaceutical developed for prostate cancer imaging, ¹⁸F-PSMA-1007, was evaluated for use as a potential replacement for ^99mTc-DMSA.

Methods: In paper I, 20 participants underwent both ¹⁸F-PSMA-1007 PET and ^99mTc-DMSA scintigraphy. Images from both modalities were compared regarding SRF and presence of defects. In paper II, estimated glomerular filtration rate (eGFR) was calculated for 170 participants having undergone ¹⁸F-PSMA-1007 PET to investigate a potential correlation between eGFR and renal uptake. In paper III, different acquisition time-points for renal ¹⁸F-PSMA-1007 PET were evaluated
regarding image quality in a cohort of 12 participants having undergone multiple image acquisitions. For paper IV, an artificial intelligence (AI) model was developed, trained and evaluated for measurement of SRF in ¹⁸F-PSMA-1007 PET based on segmentation of 215 clinical cases.

Results: The same number of uptake defects were found using ^99mTc-DMSA scintigraphy and ¹⁸F-PSMA-1007 PET. There was excellent correlation regarding SRF (r = 0.95). A moderate association (R² = 0.556) was found between eGFR and renal uptake of ¹⁸F-PSMA-1007. The optimal time-point for renal imaging was 2 hours after injection of ¹⁸F-PSMA-1007. The AI model performed similarly to human readers, making automatic measurement of SRF in clinical ¹⁸F-PSMA-1007 PET feasible.

Conclusion: Functional imaging of the renal cortex using ¹⁸F-PSMA-1007 PET is feasible, with performance similar to that of ^99mTc-DMSA scintigraphy.

Originalspråk	engelska
Kvalifikation	Doktor
Tilldelande institution	Institutionen för translationell medicin
Handledare	Trägårdh, Elin, handledare Jögi, Jonas, Biträdande handledare
Tilldelningsdatum	2026 maj 28
Utgivningsort	Lund
Förlag	Lund University, Faculty of Medicine
ISBN (tryckt)	978-91-8021-838-2
Status	Published - 2026

Bibliografisk information

Defence details
Date: 2026-05-28
Time: 13:00
Place: Föreläsningssal 1, Centralblocket, Entrégatan 7, Skånes Universitetssjukhus i Lund. Join by Zoom: https://lu-se.zoom.us/j/67265958757?pwd=NcNLcU6aD2kgt6WLuizDqH3WSZX6jT.1
External reviewer(s)
Name: Bernhardt, Peter
Title: Professor
Affiliation: Gothenburg University

FN:s Globala mål

Denna forskningsoutput relaterar till följande Globala mål

SDG 3 – God hälsa och välbefinnande

Ämnesklassifikation (UKÄ)

Radiologi och bildbehandling

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Valind, avhandlingPublicerad version, 40 MB

AI based automatic measurement of split renal function in [¹⁸F]PSMA-1007 PET/CT
Valind, K., Ulén, J., Gålne, A., Jögi, J., Minarik, D. & Trägårdh, E., 2025 dec., I: EJNMMI reports. 9, 20.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Öppen tillgång
[18F]PSMA-1007 PET is comparable to [99mTc]Tc-DMSA SPECT for renal cortical imaging.
Valind, K., Minarik, D., Garpered, S., Persson, E., Jögi, J. & Trägårdh, E., 2023 nov. 24, I: European journal of hybrid imaging. 7, 1, 25.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Öppen tillgång
[18F]PSMA-1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate
Valind, K., Jögi, J., Minarik, D. & Trägårdh, E., 2023, I: Clinical Physiology and Functional Imaging. 43, 2, s. 128-135
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Öppen tillgång

Functional imaging of the renal cortex with 18F-PSMA-1007 PET
Valind, K. (Forskarstuderande), Minarik, D. (Forskare), Jögi, J. (Biträdande handledare) & Trägårdh, E. (Handledare)
2021/03/01 → 2026/05/28
Projekt: Avhandling

Citera det här

@phdthesis{ef0cbd055a0845338a00c20f18a5396e,

title = "Functional imaging of the renal cortex with 18F-PSMA-1007 PET",

abstract = "Background: Scintigraphy of the renal cortex with technetium-99m labelled dimercaptosuccinic acid (99mTc-DMSA) is well established in the follow-up of pyelonephritis in children. This method allows detection of focal defects of renal function, as well as measurement of the relative contribution of each kidney to total renal function - split renal function (SRF). Within nuclear medicine, the long trend shows an ongoing shift from gamma camera imaging (such as with 99mTc- DMSA) to positron emission tomography (PET), mainly due to higher technical performance. In this thesis, a PET radiopharmaceutical developed for prostate cancer imaging, 18F-PSMA-1007, was evaluated for use as a potential replacement for 99mTc-DMSA. Methods: In paper I, 20 participants underwent both 18F-PSMA-1007 PET and 99mTc-DMSA scintigraphy. Images from both modalities were compared regarding SRF and presence of defects. In paper II, estimated glomerular filtration rate (eGFR) was calculated for 170 participants having undergone 18F-PSMA-1007 PET to investigate a potential correlation between eGFR and renal uptake. In paper III, different acquisition time-points for renal 18F-PSMA-1007 PET were evaluated regarding image quality in a cohort of 12 participants having undergone multiple image acquisitions. For paper IV, an artificial intelligence (AI) model was developed, trained and evaluated for measurement of SRF in 18F-PSMA-1007 PET based on segmentation of 215 clinical cases. Results: The same number of uptake defects were found using 99mTc-DMSA scintigraphy and 18F-PSMA-1007 PET. There was excellent correlation regarding SRF (r = 0.95). A moderate association (R2 = 0.556) was found between eGFR and renal uptake of 18F-PSMA-1007. The optimal time-point for renal imaging was 2 hours after injection of 18F-PSMA-1007. The AI model performed similarly to human readers, making automatic measurement of SRF in clinical 18F-PSMA-1007 PET feasible. Conclusion: Functional imaging of the renal cortex using 18F-PSMA-1007 PET is feasible, with performance similar to that of 99mTc-DMSA scintigraphy.",

keywords = "functional imaging, PET, DMSA, PSMA, renal cortex, artificial intellgience, glomerular filtration",

author = "Kristian Valind",

note = "Defence details Date: 2026-05-28 Time: 13:00 Place: F{\"o}rel{\"a}sningssal 1, Centralblocket, Entr{\'e}gatan 7, Sk{\aa}nes Universitetssjukhus i Lund. Join by Zoom: https://lu-se.zoom.us/j/67265958757?pwd=NcNLcU6aD2kgt6WLuizDqH3WSZX6jT.1 External reviewer(s) Name: Bernhardt, Peter Title: Professor Affiliation: Gothenburg University",

year = "2026",

language = "English",

isbn = "978-91-8021-838-2",

series = "Lund University, Faculty of Medicine Doctoral Dissertation Series",

publisher = "Lund University, Faculty of Medicine",

number = "2026:40",

type = "Doctoral Thesis (compilation)",

school = "Department of Translational Medicine",

}

TY - THES

T1 - Functional imaging of the renal cortex with 18F-PSMA-1007 PET

AU - Valind, Kristian

N1 - Defence details Date: 2026-05-28 Time: 13:00 Place: Föreläsningssal 1, Centralblocket, Entrégatan 7, Skånes Universitetssjukhus i Lund. Join by Zoom: https://lu-se.zoom.us/j/67265958757?pwd=NcNLcU6aD2kgt6WLuizDqH3WSZX6jT.1 External reviewer(s) Name: Bernhardt, Peter Title: Professor Affiliation: Gothenburg University

PY - 2026

Y1 - 2026

N2 - Background: Scintigraphy of the renal cortex with technetium-99m labelled dimercaptosuccinic acid (99mTc-DMSA) is well established in the follow-up of pyelonephritis in children. This method allows detection of focal defects of renal function, as well as measurement of the relative contribution of each kidney to total renal function - split renal function (SRF). Within nuclear medicine, the long trend shows an ongoing shift from gamma camera imaging (such as with 99mTc- DMSA) to positron emission tomography (PET), mainly due to higher technical performance. In this thesis, a PET radiopharmaceutical developed for prostate cancer imaging, 18F-PSMA-1007, was evaluated for use as a potential replacement for 99mTc-DMSA. Methods: In paper I, 20 participants underwent both 18F-PSMA-1007 PET and 99mTc-DMSA scintigraphy. Images from both modalities were compared regarding SRF and presence of defects. In paper II, estimated glomerular filtration rate (eGFR) was calculated for 170 participants having undergone 18F-PSMA-1007 PET to investigate a potential correlation between eGFR and renal uptake. In paper III, different acquisition time-points for renal 18F-PSMA-1007 PET were evaluated regarding image quality in a cohort of 12 participants having undergone multiple image acquisitions. For paper IV, an artificial intelligence (AI) model was developed, trained and evaluated for measurement of SRF in 18F-PSMA-1007 PET based on segmentation of 215 clinical cases. Results: The same number of uptake defects were found using 99mTc-DMSA scintigraphy and 18F-PSMA-1007 PET. There was excellent correlation regarding SRF (r = 0.95). A moderate association (R2 = 0.556) was found between eGFR and renal uptake of 18F-PSMA-1007. The optimal time-point for renal imaging was 2 hours after injection of 18F-PSMA-1007. The AI model performed similarly to human readers, making automatic measurement of SRF in clinical 18F-PSMA-1007 PET feasible. Conclusion: Functional imaging of the renal cortex using 18F-PSMA-1007 PET is feasible, with performance similar to that of 99mTc-DMSA scintigraphy.

AB - Background: Scintigraphy of the renal cortex with technetium-99m labelled dimercaptosuccinic acid (99mTc-DMSA) is well established in the follow-up of pyelonephritis in children. This method allows detection of focal defects of renal function, as well as measurement of the relative contribution of each kidney to total renal function - split renal function (SRF). Within nuclear medicine, the long trend shows an ongoing shift from gamma camera imaging (such as with 99mTc- DMSA) to positron emission tomography (PET), mainly due to higher technical performance. In this thesis, a PET radiopharmaceutical developed for prostate cancer imaging, 18F-PSMA-1007, was evaluated for use as a potential replacement for 99mTc-DMSA. Methods: In paper I, 20 participants underwent both 18F-PSMA-1007 PET and 99mTc-DMSA scintigraphy. Images from both modalities were compared regarding SRF and presence of defects. In paper II, estimated glomerular filtration rate (eGFR) was calculated for 170 participants having undergone 18F-PSMA-1007 PET to investigate a potential correlation between eGFR and renal uptake. In paper III, different acquisition time-points for renal 18F-PSMA-1007 PET were evaluated regarding image quality in a cohort of 12 participants having undergone multiple image acquisitions. For paper IV, an artificial intelligence (AI) model was developed, trained and evaluated for measurement of SRF in 18F-PSMA-1007 PET based on segmentation of 215 clinical cases. Results: The same number of uptake defects were found using 99mTc-DMSA scintigraphy and 18F-PSMA-1007 PET. There was excellent correlation regarding SRF (r = 0.95). A moderate association (R2 = 0.556) was found between eGFR and renal uptake of 18F-PSMA-1007. The optimal time-point for renal imaging was 2 hours after injection of 18F-PSMA-1007. The AI model performed similarly to human readers, making automatic measurement of SRF in clinical 18F-PSMA-1007 PET feasible. Conclusion: Functional imaging of the renal cortex using 18F-PSMA-1007 PET is feasible, with performance similar to that of 99mTc-DMSA scintigraphy.

KW - functional imaging

KW - PET

KW - DMSA

KW - PSMA

KW - renal cortex

KW - artificial intellgience

KW - glomerular filtration

M3 - Doctoral Thesis (compilation)

SN - 978-91-8021-838-2

T3 - Lund University, Faculty of Medicine Doctoral Dissertation Series

PB - Lund University, Faculty of Medicine

CY - Lund

ER -

Functional imaging of the renal cortex with 18F-PSMA-1007 PET

Sammanfattning

Bibliografisk information

FN:s Globala mål

Ämnesklassifikation (UKÄ)

Tillgång till dokument

Fingeravtryck

Forskningsoutput

AI based automatic measurement of split renal function in [18F]PSMA-1007 PET/CT

[18F]PSMA-1007 PET is comparable to [99mTc]Tc-DMSA SPECT for renal cortical imaging.

[18F]PSMA-1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

Projekt