Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration

Juan García-Revilla, Antonio Boza-Serrano, Ana M. Espinosa-Oliva, Manuel Sarmiento Soto, Tomas Deierborg, Rocío Ruiz, Rocío M. de Pablos, Miguel Angel Burguillos, Jose L. Venero

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in neuroprotection/neurotoxicity is a matter of high interest in the microglia community. In this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, TLR4 and TREM2 and the importance of galectin-3 in the regulation of microglia activation. Finally, we discuss increasing evidence supporting the involvement of this lectin in the main neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury, and stroke.

Originalspråkengelska
Artikelnummer628
TidskriftCell Death and Disease
Volym13
Nummer7
DOI
StatusPublished - 2022 juli

Ämnesklassifikation (UKÄ)

  • Neurovetenskaper

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