TY - JOUR
T1 - GBA1 T369M and Parkinson's disease - Further evidence of a lack of association in the Swedish population
AU - Brolin, Kajsa Atterling
AU - Bäckström, David
AU - Wallenius, Joel
AU - Gan-Or, Ziv
AU - Puschmann, Andreas
AU - Hansson, Oskar
AU - Swanberg, Maria
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2025/1
Y1 - 2025/1
N2 - Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808 PD patients and 2,183 controls and our results support that T369M is not a risk factor for PD in the Swedish population.
AB - Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808 PD patients and 2,183 controls and our results support that T369M is not a risk factor for PD in the Swedish population.
UR - http://www.scopus.com/inward/record.url?scp=85208201476&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2024.107191
DO - 10.1016/j.parkreldis.2024.107191
M3 - Article
C2 - 39514913
AN - SCOPUS:85208201476
SN - 1353-8020
VL - 130
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
M1 - 107191
ER -