Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome

Guðný Ella Thorlacius, Lina Hultin-Rosenberg, Johanna K Sandling, Matteo Bianchi, Juliana Imgenberg-Kreuz, Pascal Pucholt, Elke Theander, Marika Kvarnström, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Katrine B Norheim, Svein Joar Auglænd Johnsen, Daniel Hammenfors, Kathrine Skarstein, Malin V Jonsson, Eva Baecklund, Lara A Aqrawi, Janicke Liaaen Jensen, Øyvind Palm, Andrew P MorrisJennifer R S Meadows, Solbritt Rantapää-Dahlqvist, Thomas Mandl, Per Eriksson, Lars Lind, Roald Omdal, Roland Jonsson, Kerstin Lindblad-Toh, Lars Rönnblom, Marie Wahren-Herlenius, Gunnel Nordmark, DISSECT consortium

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

6 Citeringar (SciVal)

Sammanfattning

OBJECTIVES: Clinical presentation of primary Sjögren's syndrome (pSS) varies considerably. A shortage of evidence-based objective markers hinders efficient drug development and most clinical trials have failed to reach primary endpoints.

METHODS: We performed a multicentre study to identify patient subgroups based on clinical, immunological and genetic features. Targeted DNA sequencing of 1853 autoimmune-related loci was performed. After quality control, 918 patients with pSS, 1264 controls and 107 045 single nucleotide variants remained for analysis. Replication was performed in 177 patients with pSS and 7672 controls.

RESULTS: We found strong signals of association with pSS in the HLA region. Principal component analysis of clinical data distinguished two patient subgroups defined by the presence of SSA/SSB antibodies. We observed an unprecedented high risk of pSS for an association in the HLA-DQA1 locus of odds ratio 6.10 (95% CI: 4.93, 7.54, P=2.2×10-62) in the SSA/SSB-positive subgroup, while absent in the antibody negative group. Three independent signals within the MHC were observed. The two most significant variants in MHC class I and II respectively, identified patients with a higher risk of hypergammaglobulinaemia, leukopenia, anaemia, purpura, major salivary gland swelling and lymphadenopathy. Replication confirmed the association with both MHC class I and II signals confined to SSA/SSB antibody positive pSS.

CONCLUSION: Two subgroups of patients with pSS with distinct clinical manifestations can be defined by the presence or absence of SSA/SSB antibodies and genetic markers in the HLA locus. These subgroups should be considered in clinical follow-up, drug development and trial outcomes, for the benefit of both subgroups.

Originalspråkengelska
TidskriftRheumatology (Oxford, England)
DOI
StatusE-pub ahead of print - 2020 aug. 21
Externt publiceradJa

Bibliografisk information

© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology.

Ämnesklassifikation (UKÄ)

  • Reumatologi och inflammation

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