Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.

Jonas Dahlberg; Marketa Sjögren; Bo Hedblad; Gunnar Engström; Olle Melander

doi:10.1097/HJH.0000000000000044

Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.

Jonas Dahlberg, Marketa Sjögren, Bo Hedblad, Gunnar Engström, Olle Melander

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

We have previously shown that genetic variance in NEDD4L, a regulating protein of a sodium channel in the distal nephron, has been associated with marginally higher blood pressure and enhanced salt sensitivity. Here, we tested if the genetic NEDD4L variation previously associated with salt sensitivity is related to population blood pressure, incidence of cardiovascular disease (CVD) and mortality.

Originalspråk	engelska
Sidor (från-till)	294-299
Tidskrift	Journal of Hypertension
Volym	32
Nummer	2
DOI	https://doi.org/10.1097/HJH.0000000000000044
Status	Published - 2014

Ämnesklassifikation (UKÄ)

Kardiologi och kardiovaskulära sjukdomar

FN:s Globala mål

Denna forskningsoutput relaterar till följande Globala mål

Tillgång till dokument

10.1097/HJH.0000000000000044

http://www.ncbi.nlm.nih.gov/pubmed/24284497?dopt=Abstract

1 Doktorsavhandling (sammanläggning)

Genetic predisposition to salt sensitivity and cardiovascular disease
Dahlberg, J., 2014, Hypertension and Cardiovascular Disease. 68 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

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title = "Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.",

abstract = "We have previously shown that genetic variance in NEDD4L, a regulating protein of a sodium channel in the distal nephron, has been associated with marginally higher blood pressure and enhanced salt sensitivity. Here, we tested if the genetic NEDD4L variation previously associated with salt sensitivity is related to population blood pressure, incidence of cardiovascular disease (CVD) and mortality.",

author = "Jonas Dahlberg and Marketa Sj{\"o}gren and Bo Hedblad and Gunnar Engstr{\"o}m and Olle Melander",

year = "2014",

doi = "10.1097/HJH.0000000000000044",

language = "English",

volume = "32",

pages = "294--299",

journal = "Journal of Hypertension",

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publisher = "Lippincott Williams & Wilkins",

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T1 - Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.

AU - Dahlberg, Jonas

AU - Sjögren, Marketa

AU - Hedblad, Bo

AU - Engström, Gunnar

AU - Melander, Olle

PY - 2014

Y1 - 2014

N2 - We have previously shown that genetic variance in NEDD4L, a regulating protein of a sodium channel in the distal nephron, has been associated with marginally higher blood pressure and enhanced salt sensitivity. Here, we tested if the genetic NEDD4L variation previously associated with salt sensitivity is related to population blood pressure, incidence of cardiovascular disease (CVD) and mortality.

AB - We have previously shown that genetic variance in NEDD4L, a regulating protein of a sodium channel in the distal nephron, has been associated with marginally higher blood pressure and enhanced salt sensitivity. Here, we tested if the genetic NEDD4L variation previously associated with salt sensitivity is related to population blood pressure, incidence of cardiovascular disease (CVD) and mortality.

U2 - 10.1097/HJH.0000000000000044

DO - 10.1097/HJH.0000000000000044

M3 - Article

C2 - 24284497

SN - 1473-5598

VL - 32

SP - 294

EP - 299

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 2

ER -

Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.

Sammanfattning

Ämnesklassifikation (UKÄ)

FN:s Globala mål

Tillgång till dokument

Fingeravtryck

Forskningsoutput

Genetic predisposition to salt sensitivity and cardiovascular disease

Citera det här