TY - JOUR
T1 - Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study
AU - Philippe, Anne
AU - Martinez, Maria
AU - Guilloud-Bataille, Michel
AU - Gillberg, Christopher
AU - Råstam, Maria
AU - Sponheim, Eili
AU - Coleman, Mary
AU - Zappella, Michele
AU - Aschauer, Harald
AU - Van Maldergem, Lionel
AU - Penet, Christiane
AU - Feingold, Josué
AU - Brice, Alexis
AU - Leboyer, Marion
PY - 1999
Y1 - 1999
N2 - Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruited by a collaborative group including clinicians from Sweden, France, Norway, the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P -values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11-q13 region identified in previous candidate gene studies. Our study revealed six additional regions on chromosomes 4q, 5p, 6q, 10q, 18q and Xp. We found that the most significant multipoint linkage was close to marker D6S283 (maximum lod score = 2.23, P = 0.0013).
AB - Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruited by a collaborative group including clinicians from Sweden, France, Norway, the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P -values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11-q13 region identified in previous candidate gene studies. Our study revealed six additional regions on chromosomes 4q, 5p, 6q, 10q, 18q and Xp. We found that the most significant multipoint linkage was close to marker D6S283 (maximum lod score = 2.23, P = 0.0013).
UR - https://www.scopus.com/pages/publications/0032945941
U2 - 10.1093/hmg/8.5.805
DO - 10.1093/hmg/8.5.805
M3 - Article
SN - 0964-6906
VL - 8
SP - 805
EP - 812
JO - Human Molecular Genetics
JF - Human Molecular Genetics
IS - 5
ER -