Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

Weiqiang Li; Mridu Middha; Mesude Bicak; Daniel D. Sjoberg; Emily Vertosick; Anders Dahlin; Christel Häggström; Göran Hallmans; Ann Charlotte Rönn; Pär Stattin; Olle Melander; David Ulmert; Hans Lilja; Robert J. Klein

doi:10.1016/j.eururo.2018.06.021

Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

Weiqiang Li, Mridu Middha, Mesude Bicak, Daniel D. Sjoberg, Emily Vertosick, Anders Dahlin, Christel Häggström, Göran Hallmans, Ann Charlotte Rönn, Pär Stattin, Olle Melander, David Ulmert, Hans Lilja, Robert J. Klein

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

Originalspråk	engelska
Sidor (från-till)	710-719
Tidskrift	European Urology
Volym	74
Nummer	6
Tidigt onlinedatum	2018 jan. 1
DOI	https://doi.org/10.1016/j.eururo.2018.06.021
Status	Published - 2018

Ämnesklassifikation (UKÄ)

Medicinsk genetik
Cancer och onkologi

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10.1016/j.eururo.2018.06.021

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@article{8738fe3aaa6e4aeea5c05e4b81155eb4,

title = "Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival",

abstract = "We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.",

keywords = "AOX1, Expression quantitative trait locus, Genome-wide association study, Prostate cancer, Survival analysis",

author = "Weiqiang Li and Mridu Middha and Mesude Bicak and Sjoberg, {Daniel D.} and Emily Vertosick and Anders Dahlin and Christel H{\"a}ggstr{\"o}m and G{\"o}ran Hallmans and R{\"o}nn, {Ann Charlotte} and P{\"a}r Stattin and Olle Melander and David Ulmert and Hans Lilja and Klein, {Robert J.}",

year = "2018",

doi = "10.1016/j.eururo.2018.06.021",

language = "English",

volume = "74",

pages = "710--719",

journal = "European Urology",

issn = "0302-2838",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

AU - Li, Weiqiang

AU - Middha, Mridu

AU - Bicak, Mesude

AU - Sjoberg, Daniel D.

AU - Vertosick, Emily

AU - Dahlin, Anders

AU - Häggström, Christel

AU - Hallmans, Göran

AU - Rönn, Ann Charlotte

AU - Stattin, Pär

AU - Melander, Olle

AU - Ulmert, David

AU - Lilja, Hans

AU - Klein, Robert J.

PY - 2018

Y1 - 2018

N2 - We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

AB - We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

KW - AOX1

KW - Expression quantitative trait locus

KW - Genome-wide association study

KW - Prostate cancer

KW - Survival analysis

UR - http://www.scopus.com/inward/record.url?scp=85049454744&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2018.06.021

DO - 10.1016/j.eururo.2018.06.021

M3 - Article

C2 - 30289108

AN - SCOPUS:85049454744

VL - 74

SP - 710

EP - 719

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 6

ER -

Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

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