High Brain Tissue Oxygen Tension during Ventilation with 100% Oxygen after Fetal Asphyxia in Newborn Sheep.

Valéria Perez de Sá, Doris Cunha Goncalves, Anders Nord, Stefan Hansson, Anders Larsson, David Ley, Vineta Fellman, Olof Werner

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

33 Citeringar (SciVal)

Sammanfattning

The optimal FiO2 for newborn resuscitation is still not settled. We hypothesized that short-lasting oxygen ventilation after intrauterine asphyxia would not cause arterial or cerebral hyperoxia, and therefore be innocuous. The umbilical cord of fetal sheep was clamped and 10 min later, after delivery, ventilation with air (n=7) or with 100% oxygen for 3 (n=6) or 30 min (n=5), followed by air, was started. Among the eleven lambs given 100% O2, oxygen tension (PO2) was 10.7 (1.8 - 56) kPa [median (range)] in arterial samples taken after 2.5 min of ventilation. In those ventilated with 100% oxygen for 30 min, brain tissue PO2 (PbtO2) increased from less than 0.1 kPa in each lamb to individual maxima of 56 (30-61) kPa, while in those given oxygenfor just 3 min, PbtO2peaked at 4.2 (2.9 - 46) kPa. The maximal PbtO2 in air-ventilated lambs was 2.9 (0.8-5.4) kPa. Heart rate and blood pressure increased equally fast in the three groups. Thus, prolonged ventilation with 100% oxygen caused an increase in PbtO2of a magnitude previously only reported under hyperbaric conditions. Reducing the time of 100% oxygen ventilation to 3 min did not consistently avert systemic hyperoxia.
Originalspråkengelska
Sidor (från-till)57-61
TidskriftPediatric Research
VolymAug 13
DOI
StatusPublished - 2009

Ämnesklassifikation (UKÄ)

  • Pediatrik

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