High frequency of contact allergy to gold in patients with endovascular coronary stents

Susanne Ekqvist, Cecilia Svedman, Halvor Möller, M. Kehler, C. M. Pripp, Jonas Björk, Birgitta Gruvberger, E Holmstrom, C. G. Gustavsson, Magnus Bruze

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Background Stent implantation is an effective method for treatment of atherosclerotic disease. Factors predisposing to in-stent restenosis are still largely unknown. Contact allergy to metal ions eluted from the stent has been suggested to be a risk factor. Objectives To explore whether there is a possible induction of contact allergy to metals used in stents among patients with a stainless steel stent containing nickel (Ni stent) and patients with a gold-plated stent (Au stent). Methods Adults (n = 484) treated with coronary stent implantation participated in the study with patch testing. The study design was retrospective and cross-sectional with no assessment of contact allergy before stenting. Age- and sex-matched patch-tested patients with dermatitis (n = 447) served as controls. Results Of Au-stented patients, 54 of 146 (37%) were allergic to gold compared with 85 of 447 (19%) controls (P < 0.001). Within the stented population there were no statistically significant differences in contact allergy to gold or nickel between Ni-stented and Au-stented patients. In multivariate models where other risk factors for contact allergy to gold were considered, the Au stent showed a trend towards statistical significance (odds ratio 1.43, 95% confidence interval 0.95-2.16; P = 0.09). Conclusions As the frequency of contact allergy to gold is higher in stented patients independent of stent type it suggests a previous sensitization. However, several pieces of circumstantial evidence as well as statistical analysis indicate the possibility of sensitization in the coronary vessel by the Au stent. Ni stents and Au stents should not be ruled out as risk factors for induction of contact allergy to these metals.
Originalspråkengelska
Sidor (från-till)730-738
TidskriftBritish Journal of Dermatology
Volym157
Nummer4
DOI
StatusPublished - 2007

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Cardiology (013230026), Dermatology (013241300), Occupational and Environmental Dermatology Unit (013241310), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Division of Occupational and Environmental Medicine (013078001), Centre for Economic Demography (012019200)

Ämnesklassifikation (UKÄ)

  • Dermatologi och venereologi

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