Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Elin Kindberg; Britt Akerlind; Christina Johnsen; Jenny Dahl Knudsen; Ole Heltberg; Göran Larson; Blenda Böttiger; Lennart Svensson

doi:10.1128/JCM.00162-07

Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Elin Kindberg, Britt Akerlind, Christina Johnsen, Jenny Dahl Knudsen, Ole Heltberg, Göran Larson, Blenda Böttiger, Lennart Svensson

Danish Serum Institute, Copenhagen

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

Originalspråk	engelska
Sidor (från-till)	2720-2
Antal sidor	3
Tidskrift	Journal of Clinical Microbiology
Volym	45
Nummer	8
DOI	https://doi.org/10.1128/JCM.00162-07
Status	Published - 2007 aug.
Externt publicerad	Ja

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title = "Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark",

abstract = "A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.",

keywords = "Caliciviridae Infections/epidemiology, Codon, Nonsense, Denmark, Disease Outbreaks, Fucosyltransferases/genetics, Genotype, Humans, Immunity, Innate/genetics",

author = "Elin Kindberg and Britt Akerlind and Christina Johnsen and Knudsen, {Jenny Dahl} and Ole Heltberg and G{\"o}ran Larson and Blenda B{\"o}ttiger and Lennart Svensson",

year = "2007",

month = aug,

doi = "10.1128/JCM.00162-07",

language = "English",

volume = "45",

pages = "2720--2",

journal = "Journal of Clinical Microbiology",

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T1 - Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

AU - Kindberg, Elin

AU - Akerlind, Britt

AU - Johnsen, Christina

AU - Knudsen, Jenny Dahl

AU - Heltberg, Ole

AU - Larson, Göran

AU - Böttiger, Blenda

AU - Svensson, Lennart

PY - 2007/8

Y1 - 2007/8

N2 - A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

AB - A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

KW - Caliciviridae Infections/epidemiology

KW - Codon, Nonsense

KW - Denmark

KW - Disease Outbreaks

KW - Fucosyltransferases/genetics

KW - Genotype

KW - Humans

KW - Immunity, Innate/genetics

U2 - 10.1128/JCM.00162-07

DO - 10.1128/JCM.00162-07

M3 - Article

C2 - 17537929

SN - 0095-1137

VL - 45

SP - 2720

EP - 2722

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 8

ER -

Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

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