HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

Elspeth A. Bruford, Cristina R. Antonescu, Andrew J. Carroll, Arul Chinnaiyan, Ian A. Cree, Nicholas C.P. Cross, Raymond Dalgleish, Robert Peter Gale, Christine J. Harrison, Rosalind J. Hastings, Jean Loup Huret, Bertil Johansson, Michelle Le Beau, Cristina Mecucci, Fredrik Mertens, Roel Verhaak, Felix Mitelman

Forskningsoutput: TidskriftsbidragDebate/Note/EditorialPeer review


Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.

Sidor (från-till)3040-3043
Tidigt onlinedatum2021
StatusPublished - 2021

Bibliografisk information

Publisher Copyright:
© 2021, The Author(s).

Ämnesklassifikation (UKÄ)

  • Medicinsk genetik


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