HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

Elspeth A. Bruford; Cristina R. Antonescu; Andrew J. Carroll; Arul Chinnaiyan; Ian A. Cree; Nicholas C.P. Cross; Raymond Dalgleish; Robert Peter Gale; Christine J. Harrison; Rosalind J. Hastings; Jean Loup Huret; Bertil Johansson; Michelle Le Beau; Cristina Mecucci; Fredrik Mertens; Roel Verhaak; Felix Mitelman

doi:10.1038/s41375-021-01436-6

HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

Elspeth A. Bruford, Cristina R. Antonescu, Andrew J. Carroll, Arul Chinnaiyan, Ian A. Cree, Nicholas C.P. Cross, Raymond Dalgleish, Robert Peter Gale, Christine J. Harrison, Rosalind J. Hastings, Jean Loup Huret, Bertil Johansson, Michelle Le Beau, Cristina Mecucci, Fredrik Mertens, Roel Verhaak, Felix Mitelman

Forskningsoutput: Tidskriftsbidrag › Debate/Note/Editorial › Peer review

Sammanfattning

Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.

Originalspråk	engelska
Sidor (från-till)	3040-3043
Tidskrift	Leukemia
Volym	35
Nummer	11
Tidigt onlinedatum	2021
DOI	https://doi.org/10.1038/s41375-021-01436-6
Status	Published - 2021

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© 2021, The Author(s).

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Medicinsk genetik

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Bruford, E. A., Antonescu, C. R., Carroll, A. J., Chinnaiyan, A., Cree, I. A., Cross, N. C. P., Dalgleish, R., Gale, R. P., Harrison, C. J., Hastings, R. J., Huret, J. L., Johansson, B., Le Beau, M., Mecucci, C., Mertens, F., Verhaak, R., & Mitelman, F. (2021). HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions. Leukemia, 35(11), 3040-3043. https://doi.org/10.1038/s41375-021-01436-6

@article{330f14dbfbb9456bb31ec8c302e070ee,

title = "HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions",

abstract = "Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.",

author = "Bruford, {Elspeth A.} and Antonescu, {Cristina R.} and Carroll, {Andrew J.} and Arul Chinnaiyan and Cree, {Ian A.} and Cross, {Nicholas C.P.} and Raymond Dalgleish and Gale, {Robert Peter} and Harrison, {Christine J.} and Hastings, {Rosalind J.} and Huret, {Jean Loup} and Bertil Johansson and {Le Beau}, Michelle and Cristina Mecucci and Fredrik Mertens and Roel Verhaak and Felix Mitelman",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

doi = "10.1038/s41375-021-01436-6",

language = "English",

volume = "35",

pages = "3040--3043",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "11",

}

Bruford, EA, Antonescu, CR, Carroll, AJ, Chinnaiyan, A, Cree, IA, Cross, NCP, Dalgleish, R, Gale, RP, Harrison, CJ, Hastings, RJ, Huret, JL, Johansson, B, Le Beau, M, Mecucci, C, Mertens, F, Verhaak, R & Mitelman, F 2021, 'HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions', Leukemia, vol. 35, nr. 11, s. 3040-3043. https://doi.org/10.1038/s41375-021-01436-6

TY - JOUR

T1 - HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

AU - Bruford, Elspeth A.

AU - Antonescu, Cristina R.

AU - Carroll, Andrew J.

AU - Chinnaiyan, Arul

AU - Cree, Ian A.

AU - Cross, Nicholas C.P.

AU - Dalgleish, Raymond

AU - Gale, Robert Peter

AU - Harrison, Christine J.

AU - Hastings, Rosalind J.

AU - Huret, Jean Loup

AU - Johansson, Bertil

AU - Le Beau, Michelle

AU - Mecucci, Cristina

AU - Mertens, Fredrik

AU - Verhaak, Roel

AU - Mitelman, Felix

PY - 2021

Y1 - 2021

N2 - Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.

AB - Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.

U2 - 10.1038/s41375-021-01436-6

DO - 10.1038/s41375-021-01436-6

M3 - Debate/Note/Editorial

C2 - 34615987

AN - SCOPUS:85116330776

SN - 0887-6924

VL - 35

SP - 3040

EP - 3043

JO - Leukemia

JF - Leukemia

IS - 11

ER -

HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

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