Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability.

Daniel Svensson; Johannes Westman; Claes Wickström; Daniel Jönsson; Heiko Herwald; Bengt-Olof Nilsson

doi:10.1111/jre.12184

Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability.

Daniel Svensson, Johannes Westman, Claes Wickström, Daniel Jönsson, Heiko Herwald, Bengt-Olof Nilsson

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

High levels of the antimicrobial peptide, LL-37, are detected in gingival crevicular fluid from patients with chronic periodontitis. LL-37 not only shows antimicrobial activity but also affects host-cell viability. The objective of the present study was to identify endogenous mechanisms that antagonize the detrimental effects of LL-37 on osteoblast viability, focusing on the human peptide p33 expressed on the surface of various cell types.

Originalspråk	engelska
Sidor (från-till)	80-88
Tidskrift	Journal of Periodontal Research
Volym	50
Nummer	1
DOI	https://doi.org/10.1111/jre.12184
Status	Published - 2015

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Vascular Physiology (013212034), Mucosal biology (013212033), Division of Infection Medicine (BMC) (013024020)

Ämnesklassifikation (UKÄ)

Odontologi

Tillgång till dokument

10.1111/jre.12184

http://www.ncbi.nlm.nih.gov/pubmed/24697598?dopt=Abstract

1 Doktorsavhandling (sammanläggning)

Regulation of human cell viability by the host defence peptide LL-37
Svensson, D., 2017, Lund: Lund University: Faculty of Medicine. 166 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Öppen tillgång
Fil

1 Aktiva

Effects of the antimicrobial peptide LL-37 on host cell viability
Nilsson, B.-O. (PI) & Svensson, D. (Forskarstuderande)
2013/11/01 → …
Projekt: Forskning

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title = "Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability.",

abstract = "High levels of the antimicrobial peptide, LL-37, are detected in gingival crevicular fluid from patients with chronic periodontitis. LL-37 not only shows antimicrobial activity but also affects host-cell viability. The objective of the present study was to identify endogenous mechanisms that antagonize the detrimental effects of LL-37 on osteoblast viability, focusing on the human peptide p33 expressed on the surface of various cell types.",

author = "Daniel Svensson and Johannes Westman and Claes Wickstr{\"o}m and Daniel J{\"o}nsson and Heiko Herwald and Bengt-Olof Nilsson",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Vascular Physiology (013212034), Mucosal biology (013212033), Division of Infection Medicine (BMC) (013024020)",

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AU - Jönsson, Daniel

AU - Herwald, Heiko

AU - Nilsson, Bengt-Olof

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Vascular Physiology (013212034), Mucosal biology (013212033), Division of Infection Medicine (BMC) (013024020)

PY - 2015

Y1 - 2015

N2 - High levels of the antimicrobial peptide, LL-37, are detected in gingival crevicular fluid from patients with chronic periodontitis. LL-37 not only shows antimicrobial activity but also affects host-cell viability. The objective of the present study was to identify endogenous mechanisms that antagonize the detrimental effects of LL-37 on osteoblast viability, focusing on the human peptide p33 expressed on the surface of various cell types.

AB - High levels of the antimicrobial peptide, LL-37, are detected in gingival crevicular fluid from patients with chronic periodontitis. LL-37 not only shows antimicrobial activity but also affects host-cell viability. The objective of the present study was to identify endogenous mechanisms that antagonize the detrimental effects of LL-37 on osteoblast viability, focusing on the human peptide p33 expressed on the surface of various cell types.

U2 - 10.1111/jre.12184

DO - 10.1111/jre.12184

M3 - Article

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SN - 1600-0765

VL - 50

SP - 80

EP - 88

JO - Journal of Periodontal Research

JF - Journal of Periodontal Research

IS - 1

ER -

Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability.

Sammanfattning

Bibliografisk information

Ämnesklassifikation (UKÄ)

Tillgång till dokument

Fingeravtryck

Forskningsoutput

Regulation of human cell viability by the host defence peptide LL-37

Projekt

Effects of the antimicrobial peptide LL-37 on host cell viability

Citera det här