Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.

Marica Vaapil, Karolina Helczynska, René Villadsen, Ole W Petersen, Elisabet Johansson, Siv Beckman, Christer Larsson, Sven Påhlman, Annika Jögi

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

26 Citeringar (SciVal)
139 Nedladdningar (Pure)

Sammanfattning

Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially have bearing on early stages of tumorigenesis.
Originalspråkengelska
Artikelnummere46543
TidskriftPLoS ONE
Volym7
Utgåva9
DOI
StatusPublished - 2012

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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