Identification and characterization of murine glycoprotein 2-expressing intestinal dendritic cells

Katarzyna M. Luda, Clement Da Silva, Fatemeh Ahmadi, Allan Mcl Mowat, Hiroshi Ohno, Knut Kotarsky, William W. Agace

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review


The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103+CD11b+ cDC in the murine small intestine (SI). GP2 expression was induced on CD103+CD11b+ cDC within the SI-LP and was regulated by IRF4, TGFβR1- and retinoic acid signalling. Mice selectively lacking Gp2 on CD103+CD11b+ cDC (huLang-Cre.gp2fl/fl mice) had normal numbers and proportions of innate and adaptive immune cells in the SI-LP suggesting that GP2 expression by CD103+CD11b+ cDC is not required for intestinal immune homoeostasis.

Sidor (från-till)1-12
TidskriftScandinavian Journal of Immunology
StatusPublished - 2022 nov.

Bibliografisk information

Publisher Copyright:
© 2022 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology.

Ämnesklassifikation (UKÄ)

  • Immunologi inom det medicinska området


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