Forskningsoutput per år
Forskningsoutput per år
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
OBJECTIVE: A novel extended-wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non-invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.
MATERIALS AND METHODS: Extended-wavelength diffuse reflectance spectroscopy recordings (350-1550 nm) were made on 13 pigmented skin lesions and non-pigmented skin, as a reference. The hand-held probe was swept toward the pigmented area until the signal changed, thus indicating that the margin had been identified. A needle was inserted as a marker, and tissue samples were sent for histological analysis. The distance between the EWDRS-defined border and the histological border was measured by 3 independent examiners.
RESULTS: The median difference between the EWDRS-defined border and the histological border was 70 μm toward the pigmented tissue (range: -579 to 538 μm). A Pearson correlation coefficient of .95 was obtained for the examiners.
CONCLUSIONS: Extended-wavelength diffuse reflectance spectroscopy can be used in vivo to delineate the border of pigmented skin lesions in a porcine model with high accuracy, indicating that it may be a useful tool for non-invasive tumor margin delineation in the future.
Originalspråk | engelska |
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Sidor (från-till) | 667-671 |
Antal sidor | 5 |
Tidskrift | Skin Research and Technology |
Volym | 24 |
Nummer | 4 |
DOI | |
Status | Published - 2018 |
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)