Identifying and modelling clinical subpopulations from the Malmö breast tomosynthesis screening trial

B. Torlegård, A. Tingberg, S. Zackrisson, B. Barufaldi, A. D.A. Maidment, M. Dustler, P. R. Bakic

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingPeer review


Virtual Clinical Trials (VCT) are an effective tool to evaluate the performance of novel imaging systems using computer simulations. VCT results depend on the selection of virtual patient populations. In the case of breast imaging, virtual patients should be matched to a desired clinical population in terms of selected anatomical or demographic descriptors. We are developing a virtual population of women who participated in the Malmö Breast Tomosynthesis Screening Trial (MBTST). We have used clinical values of the compressed breast thickness and volumetric breast density to develop a multidimensional distribution of women in MBTST. Breast density and thickness values were obtained from anonymized, previously collected tomosynthesis images of 14,746 women. In this paper, we compare several approaches to identify clinical subpopulations and select virtual patients that represent various groups of clinical subjects. We performed two methods to identify clinical subpopulations by clustering clinical data using the K-means algorithm or woman's age. The obtained clusters have been explored and compared using the silhouette mean. The K-means algorithm yielded grouping of MBTST data into two clusters; however, that grouping was, shown to be suboptimal by the silhouette analysis. The agebased clustering showed significant overlap in terms of breast thickness and density. We also compared two approaches to select sets of representative phantoms. Our analysis has emphasized benefits and limitations of different clustering methods. The preferred method depends on the specific task that should be addressed using VCTs. Simulation of representative phantoms is ongoing. Potential correlations with pathological findings and/or parenchymal properties will be investigated.

Titel på värdpublikation15th International Workshop on Breast Imaging, IWBI 2020
RedaktörerHilde Bosmans, Nicholas Marshall, Chantal Van Ongeval
ISBN (elektroniskt)9781510638310
StatusPublished - 2020
Evenemang15th International Workshop on Breast Imaging, IWBI 2020 - Leuven, Belgien
Varaktighet: 2020 maj 252020 maj 27


NamnProceedings of SPIE - The International Society for Optical Engineering
ISSN (tryckt)0277-786X
ISSN (elektroniskt)1996-756X


Konferens15th International Workshop on Breast Imaging, IWBI 2020

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi


Utforska forskningsämnen för ”Identifying and modelling clinical subpopulations from the Malmö breast tomosynthesis screening trial”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här