Immunocytochemical demonstration of estrogen receptor beta in human periodontal ligament cells.

Daniel Jönsson, G Andersson, Eva Ekblad, Min Liang, G Bratthall, Bengt-Olof Nilsson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

28 Citeringar (SciVal)

Sammanfattning

Two transcription associated estrogen receptor (ER) subtypes have been identified and named ERα and ERβ. In the present study we investigate the expression of these ER subtypes in cultured human periodontal ligament (PDL) cells by immunocytochemistry. ERβ immunoreactivity was observed in the nuclei of about 40% of the PDL cells, while no ERα immunoreactivity was detected. In human breast cancer MCF-7 cells, serving as positive controls, both ERα and ERβ immunoreactivities were demonstrated. No immunoreactivity was observed after omission of the primary antibodies. This study suggests that estrogen acts on gene transcription preferentially via ERβ in human PDL cells.
Originalspråkengelska
Sidor (från-till)85-88
TidskriftArchives of Oral Biology
Volym49
Utgåva1
DOI
StatusPublished - 2004

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Vascular Physiology (013212034), Neurogastroenterology (013212009)

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi
  • Gastroenterologi
  • Fysiologi

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