Incident urothelial cancer in the Malmö Diet and Cancer Study: cohort characteristics and further validation of ezrin as a prognostic biomarker.

Christoffer Wennersten; Gustav Andersson; Karolina Boman; Björn Nodin; Alexander Gaber; Karin Jirström

doi:10.1186/s13000-014-0189-5

Incident urothelial cancer in the Malmö Diet and Cancer Study: cohort characteristics and further validation of ezrin as a prognostic biomarker.

Christoffer Wennersten, Gustav Andersson, Karolina Boman, Björn Nodin, Alexander Gaber, Karin Jirström

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Sammanfattning

Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with poor prognosis in urothelial bladder cancer in several independent studies. The present study provides a first description of clinicopathological characteristics of incident urothelial cancers, not only located to the bladder, in the prospective, population-based cohort study Malmö Diet and Cancer. In addition, the prognostic value of ezrin expression is validated in primary tumours, and the longitudinal expression of ezrin examined in a subset of primary and recurrent tumours (n = 28).

Originalspråk	engelska
Artikelnummer	189
Tidskrift	Diagnostic Pathology
Volym	9
Nummer	1
DOI	https://doi.org/10.1186/s13000-014-0189-5
Status	Published - 2014

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000)

Ämnesklassifikation (UKÄ)

Cancer och onkologi

FN:s Globala mål

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10.1186/s13000-014-0189-5Licens: CC BY

BMC__Wennersten_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25278252?dopt=Abstract

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title = "Incident urothelial cancer in the Malm{\"o} Diet and Cancer Study: cohort characteristics and further validation of ezrin as a prognostic biomarker.",

abstract = "Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with poor prognosis in urothelial bladder cancer in several independent studies. The present study provides a first description of clinicopathological characteristics of incident urothelial cancers, not only located to the bladder, in the prospective, population-based cohort study Malm{\"o} Diet and Cancer. In addition, the prognostic value of ezrin expression is validated in primary tumours, and the longitudinal expression of ezrin examined in a subset of primary and recurrent tumours (n = 28).",

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note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)",

year = "2014",

doi = "10.1186/s13000-014-0189-5",

language = "English",

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T1 - Incident urothelial cancer in the Malmö Diet and Cancer Study: cohort characteristics and further validation of ezrin as a prognostic biomarker.

AU - Wennersten, Christoffer

AU - Andersson, Gustav

AU - Boman, Karolina

AU - Nodin, Björn

AU - Gaber, Alexander

AU - Jirström, Karin

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)

PY - 2014

Y1 - 2014

N2 - Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with poor prognosis in urothelial bladder cancer in several independent studies. The present study provides a first description of clinicopathological characteristics of incident urothelial cancers, not only located to the bladder, in the prospective, population-based cohort study Malmö Diet and Cancer. In addition, the prognostic value of ezrin expression is validated in primary tumours, and the longitudinal expression of ezrin examined in a subset of primary and recurrent tumours (n = 28).

AB - Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with poor prognosis in urothelial bladder cancer in several independent studies. The present study provides a first description of clinicopathological characteristics of incident urothelial cancers, not only located to the bladder, in the prospective, population-based cohort study Malmö Diet and Cancer. In addition, the prognostic value of ezrin expression is validated in primary tumours, and the longitudinal expression of ezrin examined in a subset of primary and recurrent tumours (n = 28).

U2 - 10.1186/s13000-014-0189-5

DO - 10.1186/s13000-014-0189-5

M3 - Article

C2 - 25278252

SN - 1746-1596

VL - 9

JO - Diagnostic Pathology

JF - Diagnostic Pathology

IS - 1

M1 - 189

ER -

Incident urothelial cancer in the Malmö Diet and Cancer Study: cohort characteristics and further validation of ezrin as a prognostic biomarker.

Sammanfattning

Bibliografisk information

Ämnesklassifikation (UKÄ)

FN:s Globala mål

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