Inclusion of Hass avocado-oil improves postprandial metabolic responses to a hypercaloric-hyperlipidic meal in overweight subjects

In recent years, the increase of the global incidence of obesity and obesity-related disorders has been associated with metabolic imbalance and low grade inflammation. Fat-rich meals and diets contribute importantly to those alterations. The aim of this work was to evaluate the impact of exchanging butter by Hass avocado-oil on postprandial metabolic parameters in healthy overweight volunteers consuming a hypercaloric-hyperlipidic breakfast. Thirteen healthy volunteers consumed a control meal (CM) consisting of: butter, eggs, bacon, wheat bread, potatoes and iced sugar, or a test meal (TM), where butter was totally replaced by Hass avocado-oil. Blood biomarkers were measured postprandially during 240 min. Participants were 65.1 ± 5.3 years old, body mass index 28.1 ± 1.8 kg/m² and fasting glycemia ≤6.1 mmol/L. The consumption of CM or TM resulted in similar high-density lipoprotein and glucagon-like peptide-1 (GLP-1) responses, but TM improved postprandial profiles of insulin, glycemia, total cholesterol, low-density lipoprotein, triacylglycerols, C-reactive protein and interleukin-6 (P < 0.05). The study shows potential of Hass avocado-oil for counteracting the negative impact of a high fat and hypercaloric breakfast meal on important biomarkers related to cardiometabolic health.