Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival

Björn Nodin, Nooreldin Zendehrokh, Jenny Brändstedt, Elise Nilsson, Jonas Manjer, Donal J. Brennan, Karin Jirström

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

32 Citeringar (SciVal)
163 Nedladdningar (Pure)

Sammanfattning

Background: Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. Methods: In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmo Diet and Cancer Study and Malmo Preventive Project. A subset of corresponding fallopian tubes (n = 36) with no histopathological evidence of disease was also analysed. Results: While abundantly expressed in the majority of fallopian tubes with more than 75% positive nuclei in 16/36 (44%) cases, AR was absent in 108/154 (70%) of EOC cases. AR expression was not related to prognosis in the entire cohort, but in the serous subtype (n = 90), AR positivity (> 10% positive nuclei) was associated with a prolonged disease specific survival in univariate (HR= 0.49; 95% CI 0.25- 0.96; p= 0.038) and multivariate (HR= 0.46; 95% CI 0.22-0.97; p= 0.042) analysis, adjusted for age, grade and clinical stage. Conclusions: AR expression is considerably reduced in EOC as compared to fallopian tubes, and in EOC of the serous subtype, high AR expression is a favourable prognostic factor. These results indicate that assessment of AR expression might be of value for treatment stratification of EOC patients with serous ovarian carcinoma.
Originalspråkengelska
TidskriftJournal of Ovarian Research
Volym3
DOI
StatusPublished - 2010

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Surgery Research Unit (013242220), Pathology (Malmö) (013031000), Pathology, (Lund) (013030000)

Ämnesklassifikation (UKÄ)

  • Reproduktionsmedicin och gynekologi

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