Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Irma Mahmutovic Persson; Hamid Akbarshahi; Mandy Menzel; Angelica Brandelius; Lena Uller

doi:10.1186/s12967-016-0808-x

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Irma Mahmutovic Persson, Hamid Akbarshahi, Mandy Menzel, Angelica Brandelius, Lena Uller

Respiratorisk immunofarmakologi

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

Originalspråk	engelska
Artikelnummer	52
Tidskrift	Journal of Translational Medicine
Volym	14
Nummer	1
DOI	https://doi.org/10.1186/s12967-016-0808-x
Status	Published - 2016

Ämnesklassifikation (UKÄ)

Lungmedicin och allergi

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10.1186/s12967-016-0808-x

http://www.ncbi.nlm.nih.gov/pubmed/26879906?dopt=Abstract

1 Doktorsavhandling (sammanläggning)

Translational studies of viral-induced asthma and COPD exacerbations
Mahmutovic Persson, I., 2016, Lund: Lund University: Faculty of Medicine. 122 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

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title = "Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.",

abstract = "Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.",

author = "{Mahmutovic Persson}, Irma and Hamid Akbarshahi and Mandy Menzel and Angelica Brandelius and Lena Uller",

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AU - Menzel, Mandy

AU - Brandelius, Angelica

AU - Uller, Lena

PY - 2016

Y1 - 2016

N2 - Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

AB - Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

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DO - 10.1186/s12967-016-0808-x

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ER -

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Sammanfattning

Ämnesklassifikation (UKÄ)

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Translational studies of viral-induced asthma and COPD exacerbations

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