Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.

Marie Borggren, Johanna Repits, Jasminka Sterjovski, Hannes Uchtenhagen, Melissa J Churchill, Anders Karlsson, Jan Albert, Adnane Achour, Paul R Gorry, Eva Maria Fenyö, Marianne Jansson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

201 Nedladdningar (Pure)

Sammanfattning

Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.
Originalspråkengelska
Artikelnummere20135
TidskriftPLoS ONE
Volym6
Nummer6
DOI
StatusPublished - 2011

Ämnesklassifikation (UKÄ)

  • Mikrobiologi inom det medicinska området

Fingeravtryck

Utforska forskningsämnen för ”Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här