Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Matthias W. Lorenz, Horst Bickel, Michiel L. Bots, Monique M. B. Breteler, Alberico L. Catapano, Moise Desvarieux, Bo Hedblad, Bernhard Iglseder, Stein Harald Johnsen, Michal Juraska, Stefan Kiechl, Ellisiv B. Mathiesen, Giuseppe D. Norata, Liliana Grigore, Joseph Polak, Holger Poppert, Maria Rosvall, Tatjana Rundek, Ralph L. Sacco, Dirk SanderMatthias Sitzer, Helmuth Steinmetz, Eva Stensland, Johann Willeit, Jacqueline Witteman, David Yanez, Simon G. Thompson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

33 !!Citations (SciVal)

Sammanfattning

Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)
Originalspråkengelska
Sidor (från-till)730-U25
TidskriftAmerican Heart Journal
Volym159
Utgåva5
DOI
StatusPublished - 2010

Ämnesklassifikation (UKÄ)

  • Kardiologi

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