@inproceedings{9fa076e057e14d219cbb83d4ab370e70,
title = "Inhalation and dermal uptake of particle and gas phase phthalates - A human chamber exposure study",
abstract = "We have exposed sixteen test subjects to particle and gas phase phthalates in the controlled chamber exposure study. Deuterium labelled phthalates were used to generate particle D4-DEHP (di(2-ethylhexyl) phthalate) and gas phase D4-DEP (diethyl phthalate) for exposures scenarios allowed studying the dermal only and combined inhalational and dermal uptake. Metabolites were measured in urine samples before and after three hours of exposure. The inhalation was the dominant route of uptake for both DEHP and DEP in this study design and exposure settings. Larger uptake of DEP compared to DEHP both via inhalation and dermal uptake was observed. Dermal uptake of DEHP was not observed in this study. Inhalational urinary excretion factors of the metabolites were found to be 0.73 for DEHP and 0.53 for DEP. This study also highlights the importance of taking into consideration the deposited dose of inhaled particles in studies of uptake of particles.",
keywords = "Dermal exposure, Inhalation, Lung deposition, Semi-volatile organic compounds (SVOCs)",
author = "Christina Andersen and Krais, {Annette M.} and Eriksson, {Axel C.} and Jonas Jakobsson and Jakob L{\"o}ndahl and Lindh, {Christian H.} and Joakim Pagels and J{\"o}rn Nielsen and Anders Gudmundsson and Aneta Wierzbicka",
year = "2018",
language = "English",
series = "15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018",
publisher = "International Society of Indoor Air Quality and Climate (ISIAQ)",
booktitle = "15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018",
note = "15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018 ; Conference date: 22-07-2018 Through 27-07-2018",
}