Inherited genetic susceptibility to multiple myeloma

G. J. Morgan, D. C. Johnson, N. Weinhold, H. Goldschmidt, O. Landgren, H. T. Lynch, Kari Hemminki, R. S. Houlston

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.
Originalspråkengelska
Sidor (från-till)518-524
TidskriftLeukemia
Volym28
Nummer3
DOI
StatusPublished - 2014

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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