Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

J. Ose, R. T. Fortner, H. Schock, P. H. Peeters, N. C. Onland-Moret, H. B. Bueno-de-Mesquita, E. Weiderpass, I. T. Gram, K. Overvad, A. Tjonneland, L. Dossus, A. Fournier, L. Baglietto, A. Trichopoulou, V. Benetou, D. Trichopoulos, H. Boeing, G. Masala, V. Krogh, A. MatielloR. Tumino, M. Popovic, M. Obon-Santacana, N. Larranaga, E. Ardanaz, M-J Sanchez, V. Menendez, M-D Chirlaque, R. C. Travis, K-T Khaw, Jenny Brändstedt, A. Idahl, E. Lundin, S. Rinaldi, E. Kuhn, I. Romieu, M. J. Gunter, M. A. Merritt, E. Riboli, R. Kaaks

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

17 Citeringar (SciVal)
122 Nedladdningar (Pure)

Sammanfattning

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
Originalspråkengelska
Sidor (från-till)162-166
TidskriftBritish Journal of Cancer
Volym112
Utgåva1
DOI
StatusPublished - 2015

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000)

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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