Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

J. Ose; R. T. Fortner; H. Schock; P. H. Peeters; N. C. Onland-Moret; H. B. Bueno-de-Mesquita; E. Weiderpass; I. T. Gram; K. Overvad; A. Tjonneland; L. Dossus; A. Fournier; L. Baglietto; A. Trichopoulou; V. Benetou; D. Trichopoulos; H. Boeing; G. Masala; V. Krogh; A. Matiello; R. Tumino; M. Popovic; M. Obon-Santacana; N. Larranaga; E. Ardanaz; M-J Sanchez; V. Menendez; M-D Chirlaque; R. C. Travis; K-T Khaw; Jenny Brändstedt; A. Idahl; E. Lundin; S. Rinaldi; E. Kuhn; I. Romieu; M. J. Gunter; M. A. Merritt; E. Riboli; R. Kaaks

doi:10.1038/bjc.2014.566

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

J. Ose, R. T. Fortner, H. Schock, P. H. Peeters, N. C. Onland-Moret, H. B. Bueno-de-Mesquita, E. Weiderpass, I. T. Gram, K. Overvad, A. Tjonneland, L. Dossus, A. Fournier, L. Baglietto, A. Trichopoulou, V. Benetou, D. Trichopoulos, H. Boeing, G. Masala, V. Krogh, A. MatielloR. Tumino, M. Popovic, M. Obon-Santacana, N. Larranaga, E. Ardanaz, M-J Sanchez, V. Menendez, M-D Chirlaque, R. C. Travis, K-T Khaw, Jenny Brändstedt, A. Idahl, E. Lundin, S. Rinaldi, E. Kuhn, I. Romieu, M. J. Gunter, M. A. Merritt, E. Riboli, R. Kaaks

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Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

Originalspråk	engelska
Sidor (från-till)	162-166
Tidskrift	British Journal of Cancer
Volym	112
Utgåva	1
DOI	https://doi.org/10.1038/bjc.2014.566
Status	Published - 2015

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The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000)

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Cancer och onkologi

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10.1038/bjc.2014.566

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Ose, J., Fortner, R. T., Schock, H., Peeters, P. H., Onland-Moret, N. C., Bueno-de-Mesquita, H. B., Weiderpass, E., Gram, I. T., Overvad, K., Tjonneland, A., Dossus, L., Fournier, A., Baglietto, L., Trichopoulou, A., Benetou, V., Trichopoulos, D., Boeing, H., Masala, G., Krogh, V., ... Kaaks, R. (2015). Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. British Journal of Cancer, 112(1), 162-166. https://doi.org/10.1038/bjc.2014.566

Ose, J. ; Fortner, R. T. ; Schock, H. ; Peeters, P. H. ; Onland-Moret, N. C. ; Bueno-de-Mesquita, H. B. ; Weiderpass, E. ; Gram, I. T. ; Overvad, K. ; Tjonneland, A. ; Dossus, L. ; Fournier, A. ; Baglietto, L. ; Trichopoulou, A. ; Benetou, V. ; Trichopoulos, D. ; Boeing, H. ; Masala, G. ; Krogh, V. ; Matiello, A. ; Tumino, R. ; Popovic, M. ; Obon-Santacana, M. ; Larranaga, N. ; Ardanaz, E. ; Sanchez, M-J ; Menendez, V. ; Chirlaque, M-D ; Travis, R. C. ; Khaw, K-T ; Brändstedt, Jenny ; Idahl, A. ; Lundin, E. ; Rinaldi, S. ; Kuhn, E. ; Romieu, I. ; Gunter, M. J. ; Merritt, M. A. ; Riboli, E. ; Kaaks, R. / Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. I: British Journal of Cancer. 2015 ; Vol. 112, Nr. 1. s. 162-166.

@article{18e5ccfe88394eb29f1ac70dc2f09f1f,

title = "Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort",

abstract = "Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.",

keywords = "IGF-I, ovarian cancer, histological subtypes, carcinogenesis, type, I/type II, dualistic pathway",

author = "J. Ose and Fortner, {R. T.} and H. Schock and Peeters, {P. H.} and Onland-Moret, {N. C.} and Bueno-de-Mesquita, {H. B.} and E. Weiderpass and Gram, {I. T.} and K. Overvad and A. Tjonneland and L. Dossus and A. Fournier and L. Baglietto and A. Trichopoulou and V. Benetou and D. Trichopoulos and H. Boeing and G. Masala and V. Krogh and A. Matiello and R. Tumino and M. Popovic and M. Obon-Santacana and N. Larranaga and E. Ardanaz and M-J Sanchez and V. Menendez and M-D Chirlaque and Travis, {R. C.} and K-T Khaw and Jenny Br{\"a}ndstedt and A. Idahl and E. Lundin and S. Rinaldi and E. Kuhn and I. Romieu and Gunter, {M. J.} and Merritt, {M. A.} and E. Riboli and R. Kaaks",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)",

year = "2015",

doi = "10.1038/bjc.2014.566",

language = "English",

volume = "112",

pages = "162--166",

journal = "British Journal of Cancer",

issn = "1532-1827",

publisher = "Nature Publishing Group",

number = "1",

}

Ose, J, Fortner, RT, Schock, H, Peeters, PH, Onland-Moret, NC, Bueno-de-Mesquita, HB, Weiderpass, E, Gram, IT, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obon-Santacana, M, Larranaga, N, Ardanaz, E, Sanchez, M-J, Menendez, V, Chirlaque, M-D, Travis, RC, Khaw, K-T, Brändstedt, J, Idahl, A, Lundin, E, Rinaldi, S, Kuhn, E, Romieu, I, Gunter, MJ, Merritt, MA, Riboli, E & Kaaks, R 2015, 'Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort', British Journal of Cancer, vol. 112, nr. 1, s. 162-166. https://doi.org/10.1038/bjc.2014.566

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. / Ose, J.; Fortner, R. T.; Schock, H.; Peeters, P. H.; Onland-Moret, N. C.; Bueno-de-Mesquita, H. B.; Weiderpass, E.; Gram, I. T.; Overvad, K.; Tjonneland, A.; Dossus, L.; Fournier, A.; Baglietto, L.; Trichopoulou, A.; Benetou, V.; Trichopoulos, D.; Boeing, H.; Masala, G.; Krogh, V.; Matiello, A.; Tumino, R.; Popovic, M.; Obon-Santacana, M.; Larranaga, N.; Ardanaz, E.; Sanchez, M-J; Menendez, V.; Chirlaque, M-D; Travis, R. C.; Khaw, K-T; Brändstedt, Jenny; Idahl, A.; Lundin, E.; Rinaldi, S.; Kuhn, E.; Romieu, I.; Gunter, M. J.; Merritt, M. A.; Riboli, E.; Kaaks, R.

I: British Journal of Cancer, Vol. 112, Nr. 1, 2015, s. 162-166.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

TY - JOUR

T1 - Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

AU - Ose, J.

AU - Fortner, R. T.

AU - Schock, H.

AU - Peeters, P. H.

AU - Onland-Moret, N. C.

AU - Bueno-de-Mesquita, H. B.

AU - Weiderpass, E.

AU - Gram, I. T.

AU - Overvad, K.

AU - Tjonneland, A.

AU - Dossus, L.

AU - Fournier, A.

AU - Baglietto, L.

AU - Trichopoulou, A.

AU - Benetou, V.

AU - Trichopoulos, D.

AU - Boeing, H.

AU - Masala, G.

AU - Krogh, V.

AU - Matiello, A.

AU - Tumino, R.

AU - Popovic, M.

AU - Obon-Santacana, M.

AU - Larranaga, N.

AU - Ardanaz, E.

AU - Sanchez, M-J

AU - Menendez, V.

AU - Chirlaque, M-D

AU - Travis, R. C.

AU - Khaw, K-T

AU - Brändstedt, Jenny

AU - Idahl, A.

AU - Lundin, E.

AU - Rinaldi, S.

AU - Kuhn, E.

AU - Romieu, I.

AU - Gunter, M. J.

AU - Merritt, M. A.

AU - Riboli, E.

AU - Kaaks, R.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)

PY - 2015

Y1 - 2015

N2 - Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

AB - Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

KW - IGF-I

KW - ovarian cancer

KW - histological subtypes

KW - carcinogenesis

KW - type

KW - I/type II

KW - dualistic pathway

U2 - 10.1038/bjc.2014.566

DO - 10.1038/bjc.2014.566

M3 - Article

C2 - 25349976

VL - 112

SP - 162

EP - 166

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 1532-1827

IS - 1

ER -

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

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