Insulin secretion: The nitric oxide controversy

Sevda Gheibi, Asghar Ghasemi

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

8 Citeringar (SciVal)

Sammanfattning

Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that effects of NO critically depend on its concentration. Different isoforms of NO synthase (NOS) control this and have the potential to decrease or increase insulin secretion. In this review, the role of NO in insulin secretion as well as the possible reasons for discrepant findings are dis-cussed. A better understanding of the role of NO system in the regulation of insulin secretion may facilitate the development of new therapeutic strategies in the management of diabetes.

Originalspråkengelska
Sidor (från-till)1227-1245
Antal sidor19
TidskriftEXCLI Journal
Volym19
DOI
StatusPublished - 2020

Ämnesklassifikation (UKÄ)

  • Endokrinologi och diabetes

Fingeravtryck

Utforska forskningsämnen för ”Insulin secretion: The nitric oxide controversy”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här