TY - JOUR
T1 - Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population
AU - Noethlings, Ute
AU - Schulze, Matthias B.
AU - Weikert, Cornelia
AU - Boeing, Heiner
AU - van der Schouw, Yvonne T.
AU - Bamia, Christina
AU - Benetou, Vasiliki
AU - Lagiou, Pagona
AU - Krogh, Vittorio
AU - Beulens, Joline W. J.
AU - Peeters, Petra H. M.
AU - Halkjaer, Jytte
AU - Tjonneland, Anne
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Masala, Giovanna
AU - Clavel-Chapelon, Francoise
AU - de Lauzon, Blandine
AU - Boutron-Ruault, Marie-Christine
AU - Vercambre, Marie-Noel
AU - Kaaks, Rudolf
AU - Linseisen, Jakob
AU - Overvad, Kim
AU - Arriola, Larraitz
AU - Ardanaz, Eva
AU - Gonzalez, Carlos A.
AU - Tormo, Marie-Jose
AU - Bingham, Sheila
AU - Khaw, Kay-Tee
AU - Key, Tim J. A.
AU - Vineis, Paolo
AU - Riboli, Elio
AU - Ferrari, Pietro
AU - Boffetta, Paolo
AU - Bueno-de-Mesquita, H. Bas
AU - van der A, Daphne L.
AU - Berglund, Göran
AU - Wirfält, Elisabet
AU - Hallmans, Göran
AU - Johansson, Ingegerd
AU - Lund, Eiliv
AU - Trichopoulo, Antonia
PY - 2008
Y1 - 2008
N2 - We examined the associations of intake of vegetables, legumes and fruit with all-cause and cause-specific mortality in a population with prevalent diabetes in Europe. A cohort of 10,449 participants with self-reported diabetes within the European Prospective Investigation into Cancer and Nutrition study was followed for a mean of 9 y. Intakes of vegetables, legumes, and fruit were assessed at baseline between 1992 and 2000 using validated country-specific questionnaires. A total of 1346 deaths occurred. Multivariate relative risks (RR) for all-cause mortality were estimated in Cox regression models and FIR for cause-specific mortality were derived in a competing risk model. An increment in intake of total vegetables, legumes, and fruit of 80 g/d was associated with a RR of death from all causes of 0.94 [95% CI 0.90-0.98]. Analyzed separately, vegetables and legumes were associated with a significantly reduced risk, whereas nonsignificant inverse associations for fruit intake were observed. Cardiovascular disease (CVD) mortality and mortality due to non-CVD/non-cancer causes were significantly inversely associated with intake of total vegetables, legumes, and fruit (RR 0.88 [95% CI 0.81-0.95] and 0.90 [0.82-0.99], respectively) but not cancer mortality 0.08 [0.99-1.17]). Intake of vegetables, legumes, and fruit was associated with reduced risks of all-cause and CVD mortality in a diabetic population. The findings support the current state of evidence from general population studies that the protective potential of vegetable and fruit intake is larger for CVD than for cancer and suggest that diabetes patients may benefit from a diet high in vegetables and fruits.
AB - We examined the associations of intake of vegetables, legumes and fruit with all-cause and cause-specific mortality in a population with prevalent diabetes in Europe. A cohort of 10,449 participants with self-reported diabetes within the European Prospective Investigation into Cancer and Nutrition study was followed for a mean of 9 y. Intakes of vegetables, legumes, and fruit were assessed at baseline between 1992 and 2000 using validated country-specific questionnaires. A total of 1346 deaths occurred. Multivariate relative risks (RR) for all-cause mortality were estimated in Cox regression models and FIR for cause-specific mortality were derived in a competing risk model. An increment in intake of total vegetables, legumes, and fruit of 80 g/d was associated with a RR of death from all causes of 0.94 [95% CI 0.90-0.98]. Analyzed separately, vegetables and legumes were associated with a significantly reduced risk, whereas nonsignificant inverse associations for fruit intake were observed. Cardiovascular disease (CVD) mortality and mortality due to non-CVD/non-cancer causes were significantly inversely associated with intake of total vegetables, legumes, and fruit (RR 0.88 [95% CI 0.81-0.95] and 0.90 [0.82-0.99], respectively) but not cancer mortality 0.08 [0.99-1.17]). Intake of vegetables, legumes, and fruit was associated with reduced risks of all-cause and CVD mortality in a diabetic population. The findings support the current state of evidence from general population studies that the protective potential of vegetable and fruit intake is larger for CVD than for cancer and suggest that diabetes patients may benefit from a diet high in vegetables and fruits.
M3 - Article
SN - 1541-6100
VL - 138
SP - 775
EP - 781
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 4
ER -