Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects

Thomas E. Fehniger; Thomas Laurell; György Marko-Varga

doi:10.1016/j.ddtec.2005.11.005

Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects

Thomas E. Fehniger, Thomas Laurell, György Marko-Varga

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Biomarker discovery is dependent upon two disciplines: the field of clinical bioanalysis linked to disease aetiology and the application of high level technology platforms for identifying proteins/peptides in complex samples. However, diagnostic biomarker measurements require certain definitions of context that can only be achieved by combining protein science with clinical science. The evaluation of biomarkers requires careful attention to match (1) a specific biological question with (2) the appropriate clinical sample and (3) high resolution technology systems which link protein identities to clinical informatics.

Originalspråk	engelska
Sidor (från-till)	345-351
Tidskrift	Drug Discovery Today: Technologies
Volym	2
Nummer	4
DOI	https://doi.org/10.1016/j.ddtec.2005.11.005
Status	Published - 2005

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Biomedical Engineering (011200011), Analytical Chemistry (S/LTH) (011001004)

Ämnesklassifikation (UKÄ)

Analytisk kemi
Medicinteknik

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10.1016/j.ddtec.2005.11.005

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abstract = "Biomarker discovery is dependent upon two disciplines: the field of clinical bioanalysis linked to disease aetiology and the application of high level technology platforms for identifying proteins/peptides in complex samples. However, diagnostic biomarker measurements require certain definitions of context that can only be achieved by combining protein science with clinical science. The evaluation of biomarkers requires careful attention to match (1) a specific biological question with (2) the appropriate clinical sample and (3) high resolution technology systems which link protein identities to clinical informatics.",

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AU - Laurell, Thomas

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Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects

Sammanfattning

Bibliografisk information

Ämnesklassifikation (UKÄ)

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