Intensified Tuberculosis Case-Finding in HIV-Positive Adults Managed at Ethiopian Health Centers: Diagnostic Yield of Xpert MTB/RIF Compared with Smear Microscopy and Liquid Culture.

Taye Balcha; Erik Sturegård; Niclas Winqvist; Sten Skogmar; Anton Reepalu; Zelalem Habtamu Jemal; Gudeta Tibesso; Thomas Schön; Per Björkman

doi:10.1371/journal.pone.0085478

Intensified Tuberculosis Case-Finding in HIV-Positive Adults Managed at Ethiopian Health Centers: Diagnostic Yield of Xpert MTB/RIF Compared with Smear Microscopy and Liquid Culture.

Taye Balcha, Erik Sturegård, Niclas Winqvist, Sten Skogmar, Anton Reepalu, Zelalem Habtamu Jemal, Gudeta Tibesso, Thomas Schön, Per Björkman

Klinisk mikrobiologi, Malmö

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

172 Nedladdningar (Pure)

Sammanfattning

Detection of active tuberculosis (TB) before antiretroviral therapy (ART) initiation is important, but optimal diagnostic methods for use in resource-limited settings are lacking. We assessed the prevalence of TB, evaluated the diagnostic yield of Xpert MTB/RIF in comparison with smear microscopy and culture, and the impact of Xpert results on clinical management in HIV-positive adults eligible for ART at health centers in a region of Ethiopia.

Originalspråk	engelska
Artikelnummer	e85478
Tidskrift	PLoS ONE
Volym	9
Nummer	1
DOI	https://doi.org/10.1371/journal.pone.0085478
Status	Published - 2014

Ämnesklassifikation (UKÄ)

Mikrobiologi inom det medicinska området
Infektionsmedicin

FN:s Globala mål

Denna forskningsoutput relaterar till följande Globala mål

Tillgång till dokument

10.1371/journal.pone.0085478

PLoS__Balcha_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24465572?dopt=Abstract

1 Doktorsavhandling (sammanläggning)

Tuberculosis case finding in HIV-positive adults receiving care at health centres in Ethiopia
Balcha, T., 2015, Department of Clinical Sciences, Lund University. 122 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

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Balcha, T., Sturegård, E., Winqvist, N., Skogmar, S., Reepalu, A., Jemal, Z. H., Tibesso, G., Schön, T., & Björkman, P. (2014). Intensified Tuberculosis Case-Finding in HIV-Positive Adults Managed at Ethiopian Health Centers: Diagnostic Yield of Xpert MTB/RIF Compared with Smear Microscopy and Liquid Culture. PLoS ONE, 9(1), Artikel e85478. https://doi.org/10.1371/journal.pone.0085478

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abstract = "Detection of active tuberculosis (TB) before antiretroviral therapy (ART) initiation is important, but optimal diagnostic methods for use in resource-limited settings are lacking. We assessed the prevalence of TB, evaluated the diagnostic yield of Xpert MTB/RIF in comparison with smear microscopy and culture, and the impact of Xpert results on clinical management in HIV-positive adults eligible for ART at health centers in a region of Ethiopia.",

author = "Taye Balcha and Erik Stureg{\aa}rd and Niclas Winqvist and Sten Skogmar and Anton Reepalu and Jemal, {Zelalem Habtamu} and Gudeta Tibesso and Thomas Sch{\"o}n and Per Bj{\"o}rkman",

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doi = "10.1371/journal.pone.0085478",

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Balcha, T, Sturegård, E, Winqvist, N , Skogmar, S , Reepalu, A, Jemal, ZH, Tibesso, G, Schön, T & Björkman, P 2014, 'Intensified Tuberculosis Case-Finding in HIV-Positive Adults Managed at Ethiopian Health Centers: Diagnostic Yield of Xpert MTB/RIF Compared with Smear Microscopy and Liquid Culture.', PLoS ONE, vol. 9, nr. 1, e85478. https://doi.org/10.1371/journal.pone.0085478

TY - JOUR

T1 - Intensified Tuberculosis Case-Finding in HIV-Positive Adults Managed at Ethiopian Health Centers: Diagnostic Yield of Xpert MTB/RIF Compared with Smear Microscopy and Liquid Culture.

AU - Balcha, Taye

AU - Sturegård, Erik

AU - Winqvist, Niclas

AU - Skogmar, Sten

AU - Reepalu, Anton

AU - Jemal, Zelalem Habtamu

AU - Tibesso, Gudeta

AU - Schön, Thomas

AU - Björkman, Per

PY - 2014

Y1 - 2014

N2 - Detection of active tuberculosis (TB) before antiretroviral therapy (ART) initiation is important, but optimal diagnostic methods for use in resource-limited settings are lacking. We assessed the prevalence of TB, evaluated the diagnostic yield of Xpert MTB/RIF in comparison with smear microscopy and culture, and the impact of Xpert results on clinical management in HIV-positive adults eligible for ART at health centers in a region of Ethiopia.

AB - Detection of active tuberculosis (TB) before antiretroviral therapy (ART) initiation is important, but optimal diagnostic methods for use in resource-limited settings are lacking. We assessed the prevalence of TB, evaluated the diagnostic yield of Xpert MTB/RIF in comparison with smear microscopy and culture, and the impact of Xpert results on clinical management in HIV-positive adults eligible for ART at health centers in a region of Ethiopia.

U2 - 10.1371/journal.pone.0085478

DO - 10.1371/journal.pone.0085478

M3 - Article

SN - 1932-6203

VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e85478

ER -

Intensified Tuberculosis Case-Finding in HIV-Positive Adults Managed at Ethiopian Health Centers: Diagnostic Yield of Xpert MTB/RIF Compared with Smear Microscopy and Liquid Culture.

Sammanfattning

Ämnesklassifikation (UKÄ)

FN:s Globala mål

Tillgång till dokument

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Forskningsoutput

Tuberculosis case finding in HIV-positive adults receiving care at health centres in Ethiopia

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