Intestinal carriage of p fimbriated escherichia coli and the susceptibility to urinary tract infection in young children

Kaety Plos, Hugh Connell, Ulf Jodal, Britt Inger Marklund, Staffan Mårild, Björn Wettergren, Catharina Svanborg

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

This prospective study analyzed the intestinal carriage of P fimbriated Escherichia coli as a host susceptibility factor in urinary tract infection (UTI). P fimbriation was defined by the pap and G ad hesin (papG1A2prsGJ96)genotypes. Children with UTI carried pap+E. coli in the fecal flora more often than healthy controls both at diagnosis (86% vs. 29%) and during infection-free intervals (40%; P <.01). PI blood group-positive children carried pap+E. col in the fecal flora more often (88%) than those with P2 blood group (40%; P <.05). A pap+E. coli strain caused UTI in 53 of 55 patients who carried both pap+and papstrains in their fecal flora. These results suggest that persons who develop UTI have an increased tendency to carry pap+E. coli in the large intestine and that these pap+E. coli cause UTI more often than papE. coli strains in the fecal flora of the same host.

Originalspråkengelska
Sidor (från-till)625-631
TidskriftJournal of Infectious Diseases
Volym171
Nummer3
DOI
StatusPublished - 1995 mars

Ämnesklassifikation (UKÄ)

  • Infektionsmedicin
  • Pediatrik

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