TY - JOUR
T1 - Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP)
T2 - mechanisms of action
AU - Lazarus, A H
AU - Freedman, J
AU - Semple, J W
PY - 1998/9
Y1 - 1998/9
N2 - Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.
AB - Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.
KW - Antibodies, Anti-Idiotypic/immunology
KW - Autoantibodies/immunology
KW - Autoimmune Diseases/immunology
KW - Blood Platelets/immunology
KW - Clinical Trials as Topic
KW - Half-Life
KW - Humans
KW - Immunoglobulin G/immunology
KW - Immunoglobulin M/immunology
KW - Immunoglobulins, Intravenous/therapeutic use
KW - Isoantibodies/therapeutic use
KW - Macrophage Activation
KW - Mononuclear Phagocyte System/physiopathology
KW - Purpura, Thrombocytopenic, Idiopathic/immunology
KW - Rho(D) Immune Globulin
U2 - 10.1016/s0955-3886(98)00043-5
DO - 10.1016/s0955-3886(98)00043-5
M3 - Review article
C2 - 10351141
SN - 0955-3886
VL - 19
SP - 289
EP - 294
JO - Transfusion Science
JF - Transfusion Science
IS - 3
ER -