Intravenous Infusions of Purified Alpha-1 Antitripsyn Effectively Controls Symptoms and Reverts Muscle Biopsy Changes in an MZ Alpha-1 Antitripsyn Deficiency and Fibromyalgia Syndrome Patient

Ignacio Blanco Blanco, Aurora Astudillo, Francisco Dominguez Iglesias, Sabina Janciauskiene, Victoriano Carcaba Fernandez, Cesar Gallo Alvaro, Hortensia Canto Argiz, Frederick Joseph de Serres, Enrique Fernandez Bustillo

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

    6 Citeringar (SciVal)

    Sammanfattning

    Background: An MZ phenotype alpha-1 antitrypsin [AAT] deficiency and fibromyalgia syndrome [FMS] patient participated in a trial with AAT-intravenous augmentationtherapy [AAT-IV-AT] after failure of conventional therapeutic measures. Three quadricep biopsies were performed at different stages. The first one showed large aggregates of AAT and ubiquitin in myocytes and blood vessels, and moderate muscle atrophy, before AAT-IV-AT. The two remaining biopsies were performed while receiving AAT-IV-AT. Findings: Remarkably good clinical response and histological improvement in the follow-up biopsies. Conclusions: The clinical and histopathological efficacy of AAT-IV-AT evidenced in this patient should open new perspectives of research and management of AAT deficiency and FMS patients.
    Originalspråkengelska
    Sidor (från-till)167-172
    TidskriftJournal of Musculoskeletal Pain
    Volym18
    Utgåva2
    DOI
    StatusPublished - 2010

    Ämnesklassifikation (UKÄ)

    • Reumatologi och inflammation

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