Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.

Lena Erlandsson, Åsa Nääv, Annemarie Hennessy, Daniel Vaiman, Magnus Gram, Bo Åkerström, Stefan Hansson

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

25 Citeringar (SciVal)
258 Nedladdningar (Pure)

Sammanfattning

Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.
Originalspråkengelska
Sidor (från-till)402-410
TidskriftAmerican Journal of Reproductive Immunology
Volym75
Utgåva3
Tidigt onlinedatum2015 dec. 18
DOI
StatusPublished - 2016

Ämnesklassifikation (UKÄ)

  • Reproduktionsmedicin och gynekologi

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