Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Andrew P. Morris; Benjamin F. Voight; Tanya M. Teslovich; Teresa Ferreira; Ayellet V. Segre; Valgerdur Steinthorsdottir; Rona J. Strawbridge; Hassan Khan; Harald Grallert; Anubha Mahajan; Inga Prokopenko; Hyun Min Kang; Christian Dina; Tonu Esko; Ross M. Fraser; Stavroula Kanoni; Ashish Kumar; Vasiliki Lagou; Claudia Langenberg; Jian'an Luan; Cecilia M. Lindgren; Martina Mueller-Nurasyid; Sonali Pechlivanis; N. William Rayner; Laura J. Scott; Steven Wiltshire; Loic Yengo; Leena Kinnunen; Elizabeth J. Rossin; Soumya Raychaudhuri; Andrew D. Johnson; Antigone S. Dimas; Ruth J. F. Loos; Sailaja Vedantam; Han Chen; Jose C. Florez; Caroline Fox; Ching-Ti Liu; Denis Rybin; David J. Couper; Wen Hong L. Kao; Man Li; Marilyn C. Cornelis; Peter Kraft; Qi Sun; Rob M. van Dam; Heather M. Stringham; Peter S. Chines; Krista Fischer; Pierre Fontanillas; Oddgeir L. Holmen; Sarah E. Hunt; Anne U. Jackson; Augustine Kong; Robert Lawrence; Julia Meyer; John R. B. Perry; Carl G. P. Platou; Simon Potter; Emil Rehnberg; Neil Robertson; Suthesh Sivapalaratnam; Alena Stancakova; Kathleen Stirrups; Gudmar Thorleifsson; Emmi Tikkanen; Andrew R. Wood; Peter Almgren; Mustafa Atalay; Rafn Benediktsson; Lori L. Bonnycastle; Noel Burtt; Jason Carey; Guillaume Charpentier; Andrew T. Crenshaw; Alex S. F. Doney; Mozhgan Dorkhan; Sarah Edkins; Valur Emilsson; Elodie Eury; Tom Forsen; Karl Gertow; Bruna Gigante; George B. Grant; Christopher J. Groves; Candace Guiducci; Christian Herder; Astradur B. Hreidarsson; Jennie Hui; Alan James; Anna Jonsson; Wolfgang Rathmann; Norman Klopp; Jasmina Kravic; Kaarel Krjutskov; Cordelia Langford; Karin Leander; Eero Lindholm; Stephane Lobbens; Satu Mannisto; Ghazala Mirza; Thomas W. Muehleisen; Bill Musk; Melissa Parkin; Loukianos Rallidis; Jouko Saramies; Bengt Sennblad; Sonia Shah; Gunnar Sigurdsson; Angela Silveira; Gerald Steinbach; Barbara Thorand; Joseph Trakalo; Fabrizio Veglia; Roman Wennauer; Wendy Winckler; Delilah Zabaneh; Harry Campbell; Cornelia van Duijn; Andre G. Uitterlinden; Albert Hofman; Eric Sijbrands; Goncalo R. Abecasis; Katharine R. Owen; Eleftheria Zeggini; Mieke D. Trip; Nita G. Forouhi; Ann-Christine Syvanen; Johan G. Eriksson; Leena Peltonen; Markus M. Noethen; Beverley Balkau; Colin N. A. Palmer; Valeriya Lyssenko; Tiinamaija Tuomi; Bo Isomaa; David J. Hunter; Lu Qi; Alan R. Shuldiner; Michael Roden; Ines Barroso; Tom Wilsgaard; John Beilby; Kees Hovingh; Jackie F. Price; James F. Wilson; Rainer Rauramaa; Timo A. Lakka; Lars Lind; George Dedoussis; Inger Njolstad; Nancy L. Pedersen; Kay-Tee Khaw; Nicholas J. Wareham; Sirkka M. Keinanen-Kiukaanniemi; Timo E. Saaristo; Eeva Korpi-Hyovalti; Juha Saltevo; Markku Laakso; Johanna Kuusisto; Andres Metspalu; Francis S. Collins; Karen L. Mohlke; Richard N. Bergman; Jaakko Tuomilehto; Bernhard O. Boehm; Christian Gieger; Kristian Hveem; Stephane Cauchi; Philippe Froguel; Damiano Baldassarre; Elena Tremoli; Steve E. Humphries; Danish Saleheen; John Danesh; Erik Ingelsson; Samuli Ripatti; Veikko Salomaa; Raimund Erbel; Karl-Heinz Joeckel; Susanne Moebus; Annette Peters; Thomas Illig; Ulf de Faire; Anders Hamsten; Andrew D. Morris; Peter J. Donnelly; Timothy M. Frayling; Andrew T. Hattersley; Eric Boerwinkle; Olle Melander; Sekar Kathiresan; Peter Nilsson; Panos Deloukas; Unnur Thorsteinsdottir; Leif Groop; Kari Stefansson; Frank Hu; James S. Pankow; Josee Dupuis; James B. Meigs; David Altshuler; Michael Boehnke; Mark I. McCarthy

doi:10.1038/ng.2383

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Andrew P. Morris, Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segre, Valgerdur Steinthorsdottir, Rona J. Strawbridge, Hassan Khan, Harald Grallert, Anubha Mahajan, Inga Prokopenko, Hyun Min Kang, Christian Dina, Tonu Esko, Ross M. Fraser, Stavroula Kanoni, Ashish Kumar, Vasiliki Lagou, Claudia Langenberg, Jian'an LuanCecilia M. Lindgren, Martina Mueller-Nurasyid, Sonali Pechlivanis, N. William Rayner, Laura J. Scott, Steven Wiltshire, Loic Yengo, Leena Kinnunen, Elizabeth J. Rossin, Soumya Raychaudhuri, Andrew D. Johnson, Antigone S. Dimas, Ruth J. F. Loos, Sailaja Vedantam, Han Chen, Jose C. Florez, Caroline Fox, Ching-Ti Liu, Denis Rybin, David J. Couper, Wen Hong L. Kao, Man Li, Marilyn C. Cornelis, Peter Kraft, Qi Sun, Rob M. van Dam, Heather M. Stringham, Peter S. Chines, Krista Fischer, Pierre Fontanillas, Oddgeir L. Holmen, Sarah E. Hunt, Anne U. Jackson, Augustine Kong, Robert Lawrence, Julia Meyer, John R. B. Perry, Carl G. P. Platou, Simon Potter, Emil Rehnberg, Neil Robertson, Suthesh Sivapalaratnam, Alena Stancakova, Kathleen Stirrups, Gudmar Thorleifsson, Emmi Tikkanen, Andrew R. Wood, Peter Almgren, Mustafa Atalay, Rafn Benediktsson, Lori L. Bonnycastle, Noel Burtt, Jason Carey, Guillaume Charpentier, Andrew T. Crenshaw, Alex S. F. Doney, Mozhgan Dorkhan, Sarah Edkins, Valur Emilsson, Elodie Eury, Tom Forsen, Karl Gertow, Bruna Gigante, George B. Grant, Christopher J. Groves, Candace Guiducci, Christian Herder, Astradur B. Hreidarsson, Jennie Hui, Alan James, Anna Jonsson, Wolfgang Rathmann, Norman Klopp, Jasmina Kravic, Kaarel Krjutskov, Cordelia Langford, Karin Leander, Eero Lindholm, Stephane Lobbens, Satu Mannisto, Ghazala Mirza, Thomas W. Muehleisen, Bill Musk, Melissa Parkin, Loukianos Rallidis, Jouko Saramies, Bengt Sennblad, Sonia Shah, Gunnar Sigurdsson, Angela Silveira, Gerald Steinbach, Barbara Thorand, Joseph Trakalo, Fabrizio Veglia, Roman Wennauer, Wendy Winckler, Delilah Zabaneh, Harry Campbell, Cornelia van Duijn, Andre G. Uitterlinden, Albert Hofman, Eric Sijbrands, Goncalo R. Abecasis, Katharine R. Owen, Eleftheria Zeggini, Mieke D. Trip, Nita G. Forouhi, Ann-Christine Syvanen, Johan G. Eriksson, Leena Peltonen, Markus M. Noethen, Beverley Balkau, Colin N. A. Palmer, Valeriya Lyssenko, Tiinamaija Tuomi, Bo Isomaa, David J. Hunter, Lu Qi, Alan R. Shuldiner, Michael Roden, Ines Barroso, Tom Wilsgaard, John Beilby, Kees Hovingh, Jackie F. Price, James F. Wilson, Rainer Rauramaa, Timo A. Lakka, Lars Lind, George Dedoussis, Inger Njolstad, Nancy L. Pedersen, Kay-Tee Khaw, Nicholas J. Wareham, Sirkka M. Keinanen-Kiukaanniemi, Timo E. Saaristo, Eeva Korpi-Hyovalti, Juha Saltevo, Markku Laakso, Johanna Kuusisto, Andres Metspalu, Francis S. Collins, Karen L. Mohlke, Richard N. Bergman, Jaakko Tuomilehto, Bernhard O. Boehm, Christian Gieger, Kristian Hveem, Stephane Cauchi, Philippe Froguel, Damiano Baldassarre, Elena Tremoli, Steve E. Humphries, Danish Saleheen, John Danesh, Erik Ingelsson, Samuli Ripatti, Veikko Salomaa, Raimund Erbel, Karl-Heinz Joeckel, Susanne Moebus, Annette Peters, Thomas Illig, Ulf de Faire, Anders Hamsten, Andrew D. Morris, Peter J. Donnelly, Timothy M. Frayling, Andrew T. Hattersley, Eric Boerwinkle, Olle Melander, Sekar Kathiresan, Peter Nilsson, Panos Deloukas, Unnur Thorsteinsdottir, Leif Groop, Kari Stefansson, Frank Hu, James S. Pankow, Josee Dupuis, James B. Meigs, David Altshuler, Michael Boehnke, Mark I. McCarthy

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.

Originalspråk	engelska
Sidor (från-till)	981
Tidskrift	Nature Genetics
Volym	44
Nummer	9
DOI	https://doi.org/10.1038/ng.2383
Status	Published - 2012

Ämnesklassifikation (UKÄ)

Endokrinologi och diabetes
Annan klinisk medicin
Kardiologi

Tillgång till dokument

10.1038/ng.2383

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Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segre, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., Mahajan, A., Prokopenko, I., Kang, H. M., Dina, C., Esko, T., Fraser, R. M., Kanoni, S., Kumar, A., Lagou, V., Langenberg, C., ... McCarthy, M. I. (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981. https://doi.org/10.1038/ng.2383

@article{b8fc18e70d89439aa0b3792ec43d5bd6,

title = "Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes",

abstract = "To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.",

author = "Morris, {Andrew P.} and Voight, {Benjamin F.} and Teslovich, {Tanya M.} and Teresa Ferreira and Segre, {Ayellet V.} and Valgerdur Steinthorsdottir and Strawbridge, {Rona J.} and Hassan Khan and Harald Grallert and Anubha Mahajan and Inga Prokopenko and Kang, {Hyun Min} and Christian Dina and Tonu Esko and Fraser, {Ross M.} and Stavroula Kanoni and Ashish Kumar and Vasiliki Lagou and Claudia Langenberg and Jian'an Luan and Lindgren, {Cecilia M.} and Martina Mueller-Nurasyid and Sonali Pechlivanis and Rayner, {N. William} and Scott, {Laura J.} and Steven Wiltshire and Loic Yengo and Leena Kinnunen and Rossin, {Elizabeth J.} and Soumya Raychaudhuri and Johnson, {Andrew D.} and Dimas, {Antigone S.} and Loos, {Ruth J. F.} and Sailaja Vedantam and Han Chen and Florez, {Jose C.} and Caroline Fox and Ching-Ti Liu and Denis Rybin and Couper, {David J.} and Kao, {Wen Hong L.} and Man Li and Cornelis, {Marilyn C.} and Peter Kraft and Qi Sun and {van Dam}, {Rob M.} and Stringham, {Heather M.} and Chines, {Peter S.} and Krista Fischer and Pierre Fontanillas and Holmen, {Oddgeir L.} and Hunt, {Sarah E.} and Jackson, {Anne U.} and Augustine Kong and Robert Lawrence and Julia Meyer and Perry, {John R. B.} and Platou, {Carl G. P.} and Simon Potter and Emil Rehnberg and Neil Robertson and Suthesh Sivapalaratnam and Alena Stancakova and Kathleen Stirrups and Gudmar Thorleifsson and Emmi Tikkanen and Wood, {Andrew R.} and Peter Almgren and Mustafa Atalay and Rafn Benediktsson and Bonnycastle, {Lori L.} and Noel Burtt and Jason Carey and Guillaume Charpentier and Crenshaw, {Andrew T.} and Doney, {Alex S. F.} and Mozhgan Dorkhan and Sarah Edkins and Valur Emilsson and Elodie Eury and Tom Forsen and Karl Gertow and Bruna Gigante and Grant, {George B.} and Groves, {Christopher J.} and Candace Guiducci and Christian Herder and Hreidarsson, {Astradur B.} and Jennie Hui and Alan James and Anna Jonsson and Wolfgang Rathmann and Norman Klopp and Jasmina Kravic and Kaarel Krjutskov and Cordelia Langford and Karin Leander and Eero Lindholm and Stephane Lobbens and Satu Mannisto and Ghazala Mirza and Muehleisen, {Thomas W.} and Bill Musk and Melissa Parkin and Loukianos Rallidis and Jouko Saramies and Bengt Sennblad and Sonia Shah and Gunnar Sigurdsson and Angela Silveira and Gerald Steinbach and Barbara Thorand and Joseph Trakalo and Fabrizio Veglia and Roman Wennauer and Wendy Winckler and Delilah Zabaneh and Harry Campbell and {van Duijn}, Cornelia and Uitterlinden, {Andre G.} and Albert Hofman and Eric Sijbrands and Abecasis, {Goncalo R.} and Owen, {Katharine R.} and Eleftheria Zeggini and Trip, {Mieke D.} and Forouhi, {Nita G.} and Ann-Christine Syvanen and Eriksson, {Johan G.} and Leena Peltonen and Noethen, {Markus M.} and Beverley Balkau and Palmer, {Colin N. A.} and Valeriya Lyssenko and Tiinamaija Tuomi and Bo Isomaa and Hunter, {David J.} and Lu Qi and Shuldiner, {Alan R.} and Michael Roden and Ines Barroso and Tom Wilsgaard and John Beilby and Kees Hovingh and Price, {Jackie F.} and Wilson, {James F.} and Rainer Rauramaa and Lakka, {Timo A.} and Lars Lind and George Dedoussis and Inger Njolstad and Pedersen, {Nancy L.} and Kay-Tee Khaw and Wareham, {Nicholas J.} and Keinanen-Kiukaanniemi, {Sirkka M.} and Saaristo, {Timo E.} and Eeva Korpi-Hyovalti and Juha Saltevo and Markku Laakso and Johanna Kuusisto and Andres Metspalu and Collins, {Francis S.} and Mohlke, {Karen L.} and Bergman, {Richard N.} and Jaakko Tuomilehto and Boehm, {Bernhard O.} and Christian Gieger and Kristian Hveem and Stephane Cauchi and Philippe Froguel and Damiano Baldassarre and Elena Tremoli and Humphries, {Steve E.} and Danish Saleheen and John Danesh and Erik Ingelsson and Samuli Ripatti and Veikko Salomaa and Raimund Erbel and Karl-Heinz Joeckel and Susanne Moebus and Annette Peters and Thomas Illig and {de Faire}, Ulf and Anders Hamsten and Morris, {Andrew D.} and Donnelly, {Peter J.} and Frayling, {Timothy M.} and Hattersley, {Andrew T.} and Eric Boerwinkle and Olle Melander and Sekar Kathiresan and Peter Nilsson and Panos Deloukas and Unnur Thorsteinsdottir and Leif Groop and Kari Stefansson and Frank Hu and Pankow, {James S.} and Josee Dupuis and Meigs, {James B.} and David Altshuler and Michael Boehnke and McCarthy, {Mark I.}",

year = "2012",

doi = "10.1038/ng.2383",

language = "English",

volume = "44",

pages = "981",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Publishing Group",

number = "9",

}

Morris, AP, Voight, BF, Teslovich, TM, Ferreira, T, Segre, AV, Steinthorsdottir, V, Strawbridge, RJ, Khan, H, Grallert, H, Mahajan, A, Prokopenko, I, Kang, HM, Dina, C, Esko, T, Fraser, RM, Kanoni, S, Kumar, A, Lagou, V, Langenberg, C, Luan, J, Lindgren, CM, Mueller-Nurasyid, M, Pechlivanis, S, Rayner, NW, Scott, LJ, Wiltshire, S, Yengo, L, Kinnunen, L, Rossin, EJ, Raychaudhuri, S, Johnson, AD, Dimas, AS, Loos, RJF, Vedantam, S, Chen, H, Florez, JC, Fox, C, Liu, C-T, Rybin, D, Couper, DJ, Kao, WHL, Li, M, Cornelis, MC, Kraft, P, Sun, Q, van Dam, RM, Stringham, HM, Chines, PS, Fischer, K, Fontanillas, P, Holmen, OL, Hunt, SE, Jackson, AU, Kong, A, Lawrence, R, Meyer, J, Perry, JRB, Platou, CGP, Potter, S, Rehnberg, E, Robertson, N, Sivapalaratnam, S, Stancakova, A, Stirrups, K, Thorleifsson, G, Tikkanen, E, Wood, AR, Almgren, P, Atalay, M, Benediktsson, R, Bonnycastle, LL, Burtt, N, Carey, J, Charpentier, G, Crenshaw, AT, Doney, ASF, Dorkhan, M, Edkins, S, Emilsson, V, Eury, E, Forsen, T, Gertow, K, Gigante, B, Grant, GB, Groves, CJ, Guiducci, C, Herder, C, Hreidarsson, AB, Hui, J, James, A, Jonsson, A, Rathmann, W, Klopp, N, Kravic, J, Krjutskov, K, Langford, C, Leander, K, Lindholm, E, Lobbens, S, Mannisto, S, Mirza, G, Muehleisen, TW, Musk, B, Parkin, M, Rallidis, L, Saramies, J, Sennblad, B, Shah, S, Sigurdsson, G, Silveira, A, Steinbach, G, Thorand, B, Trakalo, J, Veglia, F, Wennauer, R, Winckler, W, Zabaneh, D, Campbell, H, van Duijn, C, Uitterlinden, AG, Hofman, A, Sijbrands, E, Abecasis, GR, Owen, KR, Zeggini, E, Trip, MD, Forouhi, NG, Syvanen, A-C, Eriksson, JG, Peltonen, L, Noethen, MM, Balkau, B, Palmer, CNA, Lyssenko, V, Tuomi, T, Isomaa, B, Hunter, DJ, Qi, L, Shuldiner, AR, Roden, M, Barroso, I, Wilsgaard, T, Beilby, J, Hovingh, K, Price, JF, Wilson, JF, Rauramaa, R, Lakka, TA, Lind, L, Dedoussis, G, Njolstad, I, Pedersen, NL, Khaw, K-T, Wareham, NJ, Keinanen-Kiukaanniemi, SM, Saaristo, TE, Korpi-Hyovalti, E, Saltevo, J, Laakso, M, Kuusisto, J, Metspalu, A, Collins, FS, Mohlke, KL, Bergman, RN, Tuomilehto, J, Boehm, BO, Gieger, C, Hveem, K, Cauchi, S, Froguel, P, Baldassarre, D, Tremoli, E, Humphries, SE, Saleheen, D, Danesh, J, Ingelsson, E, Ripatti, S, Salomaa, V, Erbel, R, Joeckel, K-H, Moebus, S, Peters, A, Illig, T, de Faire, U, Hamsten, A, Morris, AD, Donnelly, PJ, Frayling, TM, Hattersley, AT, Boerwinkle, E, Melander, O, Kathiresan, S, Nilsson, P, Deloukas, P, Thorsteinsdottir, U, Groop, L, Stefansson, K, Hu, F, Pankow, JS, Dupuis, J, Meigs, JB, Altshuler, D, Boehnke, M & McCarthy, MI 2012, 'Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes', Nature Genetics, vol. 44, nr. 9, s. 981. https://doi.org/10.1038/ng.2383

TY - JOUR

T1 - Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

AU - Morris, Andrew P.

AU - Voight, Benjamin F.

AU - Teslovich, Tanya M.

AU - Ferreira, Teresa

AU - Segre, Ayellet V.

AU - Steinthorsdottir, Valgerdur

AU - Strawbridge, Rona J.

AU - Khan, Hassan

AU - Grallert, Harald

AU - Mahajan, Anubha

AU - Prokopenko, Inga

AU - Kang, Hyun Min

AU - Dina, Christian

AU - Esko, Tonu

AU - Fraser, Ross M.

AU - Kanoni, Stavroula

AU - Kumar, Ashish

AU - Lagou, Vasiliki

AU - Langenberg, Claudia

AU - Luan, Jian'an

AU - Lindgren, Cecilia M.

AU - Mueller-Nurasyid, Martina

AU - Pechlivanis, Sonali

AU - Rayner, N. William

AU - Scott, Laura J.

AU - Wiltshire, Steven

AU - Yengo, Loic

AU - Kinnunen, Leena

AU - Rossin, Elizabeth J.

AU - Raychaudhuri, Soumya

AU - Johnson, Andrew D.

AU - Dimas, Antigone S.

AU - Loos, Ruth J. F.

AU - Vedantam, Sailaja

AU - Chen, Han

AU - Florez, Jose C.

AU - Fox, Caroline

AU - Liu, Ching-Ti

AU - Rybin, Denis

AU - Couper, David J.

AU - Kao, Wen Hong L.

AU - Li, Man

AU - Cornelis, Marilyn C.

AU - Kraft, Peter

AU - Sun, Qi

AU - van Dam, Rob M.

AU - Stringham, Heather M.

AU - Chines, Peter S.

AU - Fischer, Krista

AU - Fontanillas, Pierre

AU - Holmen, Oddgeir L.

AU - Hunt, Sarah E.

AU - Jackson, Anne U.

AU - Kong, Augustine

AU - Lawrence, Robert

AU - Meyer, Julia

AU - Perry, John R. B.

AU - Platou, Carl G. P.

AU - Potter, Simon

AU - Rehnberg, Emil

AU - Robertson, Neil

AU - Sivapalaratnam, Suthesh

AU - Stancakova, Alena

AU - Stirrups, Kathleen

AU - Thorleifsson, Gudmar

AU - Tikkanen, Emmi

AU - Wood, Andrew R.

AU - Almgren, Peter

AU - Atalay, Mustafa

AU - Benediktsson, Rafn

AU - Bonnycastle, Lori L.

AU - Burtt, Noel

AU - Carey, Jason

AU - Charpentier, Guillaume

AU - Crenshaw, Andrew T.

AU - Doney, Alex S. F.

AU - Dorkhan, Mozhgan

AU - Edkins, Sarah

AU - Emilsson, Valur

AU - Eury, Elodie

AU - Forsen, Tom

AU - Gertow, Karl

AU - Gigante, Bruna

AU - Grant, George B.

AU - Groves, Christopher J.

AU - Guiducci, Candace

AU - Herder, Christian

AU - Hreidarsson, Astradur B.

AU - Hui, Jennie

AU - James, Alan

AU - Jonsson, Anna

AU - Rathmann, Wolfgang

AU - Klopp, Norman

AU - Kravic, Jasmina

AU - Krjutskov, Kaarel

AU - Langford, Cordelia

AU - Leander, Karin

AU - Lindholm, Eero

AU - Lobbens, Stephane

AU - Mannisto, Satu

AU - Mirza, Ghazala

AU - Muehleisen, Thomas W.

AU - Musk, Bill

AU - Parkin, Melissa

AU - Rallidis, Loukianos

AU - Saramies, Jouko

AU - Sennblad, Bengt

AU - Shah, Sonia

AU - Sigurdsson, Gunnar

AU - Silveira, Angela

AU - Steinbach, Gerald

AU - Thorand, Barbara

AU - Trakalo, Joseph

AU - Veglia, Fabrizio

AU - Wennauer, Roman

AU - Winckler, Wendy

AU - Zabaneh, Delilah

AU - Campbell, Harry

AU - van Duijn, Cornelia

AU - Uitterlinden, Andre G.

AU - Hofman, Albert

AU - Sijbrands, Eric

AU - Abecasis, Goncalo R.

AU - Owen, Katharine R.

AU - Zeggini, Eleftheria

AU - Trip, Mieke D.

AU - Forouhi, Nita G.

AU - Syvanen, Ann-Christine

AU - Eriksson, Johan G.

AU - Peltonen, Leena

AU - Noethen, Markus M.

AU - Balkau, Beverley

AU - Palmer, Colin N. A.

AU - Lyssenko, Valeriya

AU - Tuomi, Tiinamaija

AU - Isomaa, Bo

AU - Hunter, David J.

AU - Qi, Lu

AU - Shuldiner, Alan R.

AU - Roden, Michael

AU - Barroso, Ines

AU - Wilsgaard, Tom

AU - Beilby, John

AU - Hovingh, Kees

AU - Price, Jackie F.

AU - Wilson, James F.

AU - Rauramaa, Rainer

AU - Lakka, Timo A.

AU - Lind, Lars

AU - Dedoussis, George

AU - Njolstad, Inger

AU - Pedersen, Nancy L.

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas J.

AU - Keinanen-Kiukaanniemi, Sirkka M.

AU - Saaristo, Timo E.

AU - Korpi-Hyovalti, Eeva

AU - Saltevo, Juha

AU - Laakso, Markku

AU - Kuusisto, Johanna

AU - Metspalu, Andres

AU - Collins, Francis S.

AU - Mohlke, Karen L.

AU - Bergman, Richard N.

AU - Tuomilehto, Jaakko

AU - Boehm, Bernhard O.

AU - Gieger, Christian

AU - Hveem, Kristian

AU - Cauchi, Stephane

AU - Froguel, Philippe

AU - Baldassarre, Damiano

AU - Tremoli, Elena

AU - Humphries, Steve E.

AU - Saleheen, Danish

AU - Danesh, John

AU - Ingelsson, Erik

AU - Ripatti, Samuli

AU - Salomaa, Veikko

AU - Erbel, Raimund

AU - Joeckel, Karl-Heinz

AU - Moebus, Susanne

AU - Peters, Annette

AU - Illig, Thomas

AU - de Faire, Ulf

AU - Hamsten, Anders

AU - Morris, Andrew D.

AU - Donnelly, Peter J.

AU - Frayling, Timothy M.

AU - Hattersley, Andrew T.

AU - Boerwinkle, Eric

AU - Melander, Olle

AU - Kathiresan, Sekar

AU - Nilsson, Peter

AU - Deloukas, Panos

AU - Thorsteinsdottir, Unnur

AU - Groop, Leif

AU - Stefansson, Kari

AU - Hu, Frank

AU - Pankow, James S.

AU - Dupuis, Josee

AU - Meigs, James B.

AU - Altshuler, David

AU - Boehnke, Michael

AU - McCarthy, Mark I.

PY - 2012

Y1 - 2012

N2 - To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.

AB - To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.

U2 - 10.1038/ng.2383

DO - 10.1038/ng.2383

M3 - Article

C2 - 22885922

VL - 44

SP - 981

JO - Nature Genetics

JF - Nature Genetics

SN - 1546-1718

IS - 9

ER -

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

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