TY - JOUR
T1 - Latest developments in metal complexes as anticancer agents
AU - Paprocka, Renata
AU - Wiese-Szadkowska, Małgorzata
AU - Janciauskiene, Sabina
AU - Kosmalski, Tomasz
AU - Kulik, Marcelina
AU - Helmin-Basa, Anna
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2022
Y1 - 2022
N2 - Every year novel biologically active compounds are designed as antitumor agents. This review covers and highlights some of the most important findings described during 2018–2020 to appoint the benefits and drawbacks regarding the activity and toxicity of the metal-based cancer drug candidates. We review new multi-action platinum(IV) prodrugs and other metal complexes with high chemotherapeutic potential, which are designed to overcome cisplatin-resistant cancer cells. We also overview new complexes of Os(II), Ru(II), Ir(III), and Zn(II) used for photodynamic therapy, as well as the complexes conjugated with conventional drugs exhibiting new mechanisms of action. Promising complexes that exceed the selectivity of cisplatin, highly effective in vitro and in vivo, against certain types of neoplasms are distinguished in the lung, colon, liver, stomach, breast cancers and others.
AB - Every year novel biologically active compounds are designed as antitumor agents. This review covers and highlights some of the most important findings described during 2018–2020 to appoint the benefits and drawbacks regarding the activity and toxicity of the metal-based cancer drug candidates. We review new multi-action platinum(IV) prodrugs and other metal complexes with high chemotherapeutic potential, which are designed to overcome cisplatin-resistant cancer cells. We also overview new complexes of Os(II), Ru(II), Ir(III), and Zn(II) used for photodynamic therapy, as well as the complexes conjugated with conventional drugs exhibiting new mechanisms of action. Promising complexes that exceed the selectivity of cisplatin, highly effective in vitro and in vivo, against certain types of neoplasms are distinguished in the lung, colon, liver, stomach, breast cancers and others.
KW - Antitumor activity
KW - Cisplatin
KW - Cytotoxicity, in vivo
KW - Photodynamic therapy
KW - Prodrug
U2 - 10.1016/j.ccr.2021.214307
DO - 10.1016/j.ccr.2021.214307
M3 - Review article
AN - SCOPUS:85119366566
SN - 0010-8545
VL - 452
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 214307
ER -
