Leukemia associated mutant Wilms' tumor gene 1 protein promotes expansion of human hematopoietic progenitor cells.

Karina Vidovic, Tove Ullmark, Bodil Rosberg, Andreas Lennartsson, Tor Olofsson, Björn Nilsson, Urban Gullberg

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

322 Nedladdningar (Pure)

Sammanfattning

The transcription factor Wilms' tumor gene 1 (WT1) is highly expressed in the majority of leukemias, suggesting a role in leukemogenesis. Acquired WT1 mutations are reported as an independent predictor of poor clinical outcome, and mutations resulting in deletion of the entire DNA-binding zinc-finger domain (WT1delZ), is the most common type. The aim of this study was to study cellular effects of WT1(delZ) that may contribute to an oncogenic phenotype. We found that expression of WT1(delZ) supported proliferation of human hematopoietic CD34(+) progenitor cells. Moreover, WT1(delZ) transduced cells expressed erythroid markers, including raised levels of STAT5, independently of addition of erythropoietin. At the global gene expression level, WT1(delZ) caused upregulation of genes related to cell division and genes associated with erythroid maturation, in the absence of added erythropoietin. Our results indicate that WT1(delZ) promotes cell proliferation and expansion of progenitor cells, consistent with a possible role in leukemogenesis.
Originalspråkengelska
Sidor (från-till)1341-1349
TidskriftLeukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volym37
Nummer10
DOI
StatusPublished - 2013

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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