Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies

Harindra Jayasekara, Robert J. MacInnis, Leila Lujan-Barroso, Ana Lucia Mayen-Chacon, Amanda J. Cross, Bengt Wallner, Domenico Palli, Fulvio Ricceri, Valeria Pala, Salvatore Panico, Rosario Tumino, Tilman Kühn, Rudolf Kaaks, Kostas Tsilidis, Maria Jose Sánchez, Pilar Amiano, Eva Ardanaz, María Dolores Chirlaque López, Susana Merino, Joseph A. RothwellMarie Christine Boutron-Ruault, Gianluca Severi, Hanna Sternby, Emily Sonestedt, Bas Bueno-de-Mesquita, Heiner Boeing, Ruth Travis, Torkjel M. Sandanger, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Anne Tjønneland, Yi Yang, Allison M. Hodge, Hazel Mitchell, Andrew Haydon, Robin Room, John L. Hopper, Elisabete Weiderpass, Marc J. Gunter, Elio Riboli, Graham G. Giles, Roger L. Milne, Antonio Agudo, Dallas R. English, Pietro Ferrari

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity =.02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.

Originalspråkengelska
Sidor (från-till)2759-2773
TidskriftInternational Journal of Cancer
Volym148
Nummer11
Tidigt onlinedatum2021 feb. 7
DOI
StatusPublished - 2021

Ämnesklassifikation (UKÄ)

  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
  • Cancer och onkologi

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