Projekt per år
Sammanfattning
The lack of methods to evaluate mechanical function of donated hearts in the context of transplantation imposes large precautionary margins, translating into a low utilization rate of donor organs. This has spawned research into cyber-physical models constituting artificial afterloads (arterial trees), that can serve to evaluate the contractile capacity of the donor heart. The Windkessel model is an established linear time-invariant afterload model, that researchers committed to creating a cyber-physical afterload have used as a template. With aortic volumetric flow as input and aortic pressure as output, it is not directly obvious how a Windkessel model will respond to changes in heart contractility. We transform the classic Windkessel model to relate power, rather than flow, to pressure. This alters the model into a differential-algebraic equation, albeit one that is straightforward to simulate. We then propose a power signal model, that is based on pressure and flow measurements and optimal in a Bayesian sense within the class of C2 signals. Finally, we show how the proposed signal model can be used to create relevant simulation scenarios, and use this to illustrate why it is problematic to use the Windkessel model as a basis for designing a clinically relevant artificial afterload.
Originalspråk | engelska |
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Titel på värdpublikation | American Control Conference |
Sidor | 2994-2999 |
Volym | 2022 |
DOI | |
Status | Published - 2022 |
Evenemang | American Control Conference, 2022 - Atlanta, GA, USA Varaktighet: 2022 juni 8 → 2022 juni 10 https://acc2022.a2c2.org/ |
Konferens
Konferens | American Control Conference, 2022 |
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Förkortad titel | ACC |
Land/Territorium | USA |
Ort | GA |
Period | 2022/06/08 → 2022/06/10 |
Internetadress |
Ämnesklassifikation (UKÄ)
- Reglerteknik
Fingeravtryck
Utforska forskningsämnen för ”Limitations of time-delayed case isolation in heterogeneous SIR models”. Tillsammans bildar de ett unikt fingeravtryck.Projekt
- 1 Avslutade
-
COVID-19: Dynamical modelling for estimation and prediction
Bernhardsson, B. (Forskare), Eker, J. (Forskare), Govaert, A. (Forskare), Gustafsson, F. (Forskare), Hansson, J. (Forskare), Heimerson, A. (Forskare), Jaldén, J. (Forskare), Jidling, C. (Forskare), Jöud, A. (Forskare), Pates, R. (Forskare), B. Schön, T. (Forskare), Soltesz, K. (Forskare), Spreco, A. (Forskare), Tegling, E. (Forskare), Timpka, T. (Forskare), Wacker, A. (Forskare), Hendeby, G. (Forskare) & Rath, A. (Forskarstuderande)
2020/01/01 → 2022/12/31
Projekt: Forskning