Lung Function and CT Densitometry in Subjects with alpha-1-Antitrypsin Deficiency and Healthy Controls at 35 Years of Age.

Eeva Piitulainen, Laura Cano Montero, Meltem Nystedt-Düzakin, Berend C Stoel, Tomas Sveger, Per Wollmer, Hanan Tanash, Sandra Diaz

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

23 Citeringar (SciVal)

Sammanfattning

Abstract Alpha-1-antitrypsin (AAT) deficiency is a genetic risk factor for pulmonary emphysema. In 1972-74 all 200,000 Swedish new-born infants were screened for AAT deficiency. The aim of the present study was to investigate whether the PiZZ and PiSZ individuals identified by this screening have signs of emphysema and the role of smoking in this, compared with a random sample of control subjects at 35 years of age. The study participants underwent complete pulmonary function tests (PFT) and CT densitometry. The fifteenth percentile density (PD15) and the relative area below -910 HU (RA-910) were analyzed. Fifty-four PiZZ, 21 PiSZ and 66 PiMM control subjects participated in the study. No significant differences were found in lung function between the never-smoking AAT-deficient and control subjects. The 16 PiZZ ever-smokers had significantly lower carbon monoxide transfer coefficient (KCO) than the 20 PiSZ never-smokers (p = 0.014) and the 44 PiMM never-smokers (p = 0.005). After correction for the CT derived lung volume, the PiZZ ever-smokers had significantly lower PD15 (p = 0.046) than the ever-smoking controls. We conclude that 35-year-old PiZZ and PiSZ never-smokers have normal lung function when compared with never-smoking control subjects. The differences in KCO and CT densitometric parameters between the PiZZ ever-smokers and the control subjects may indicate early signs of emphysema.
Originalspråkengelska
Sidor (från-till)162-167
TidskriftCOPD: Journal of Chronic Obstructive Pulmonary Disease
Volym12
Utgåva2
DOI
StatusPublished - 2015

Ämnesklassifikation (UKÄ)

  • Lungmedicin och allergi

Fingeravtryck

Utforska forskningsämnen för ”Lung Function and CT Densitometry in Subjects with alpha-1-Antitrypsin Deficiency and Healthy Controls at 35 Years of Age.”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här