TY - JOUR
T1 - Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.
AU - Böiers, Charlotta
AU - Carrelha, Joana
AU - Lutteropp, Michael
AU - Luc, Sidinh
AU - Green, Joanna C A
AU - Azzoni, Emanuele
AU - Woll, Petter S
AU - Mead, Adam J
AU - Hultquist, Anne
AU - Swiers, Gemma
AU - Perdiguero, Elisa Gomez
AU - Macaulay, Iain C
AU - Melchiori, Luca
AU - Luis, Tiago C
AU - Kharazi, Shabnam
AU - Bouriez-Jones, Tiphaine
AU - Deng, Qiaolin
AU - Pontén, Annica
AU - Atkinson, Deborah
AU - Jensen, Christina
AU - Sitnicka Quinn, Ewa
AU - Geissmann, Frederic
AU - Godin, Isabelle
AU - Sandberg, Rickard
AU - de Bruijn, Marella F T R
AU - Jacobsen, Sten Eirik W
PY - 2013
Y1 - 2013
N2 - In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.
AB - In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.
U2 - 10.1016/j.stem.2013.08.012
DO - 10.1016/j.stem.2013.08.012
M3 - Article
C2 - 24054998
SN - 1934-5909
VL - 13
SP - 535
EP - 548
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 5
ER -